Combination treatment for metastatic castration-resistant prostate cancer may be especially effective for people with BRCA1 or BRCA2 mutations

Questions To Ask Your Health Care Provider

I have mCRPC:

• Does my tumor have a mutation in an HRR gene?
• Should I consider having genetic testing for an inherited mutation? What tests should I have?
• Based on my genetic test results, what information should my blood relatives know?
• What treatments are recommended for my cancer?
• What side effects might occur during my treatment?

Open Clinical Trials

The following treatment studies are enrolling people with advanced prostate cancer: 

• NCT05011383: High Dose Testosterone Treatment for People with Metastatic Prostate Cancer and an ATM, CDK12 or CHEK2 Mutation. This study will examine how well an increased dose of testosterone treatment works for people with metastatic castration-resistant prostate cancer (mCRPC) with an ATM, CDK12, or CHEK2 genetic mutation.
• NCT05367440: Treating Metastatic Prostate Cancer with a New PARP Inhibitor AZD5305 Combined With Hormone Therapy. This study will look at the effectiveness of a new PARP inhibitor drug called AZD5305 in combination with different hormone therapies to treat metastatic prostate cancer, compared to the current standard treatment. 
• NCT04038502: Treating Metastatic Prostate Cancer with Chemotherapy or PARP Inhibitor in People with Mutations (COBRA). This study is comparing carboplatin chemotherapy to the PARP inhibitor, olaparib as first-line treatment for metastatic castration-resistant prostate cancer in people with a BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2, RAD51B, RAD51C, RAD51D or RAD54L mutation.
• NCT06120491: Studying the Effectiveness of New PARP Inhibitor, Saruparib Compared to Current Treatment Options for Metastatic Prostate Cancer EvoPAR-PRO1. This study will evaluate an investigational PARP inhibitor drug called Saruparib in combination with new hormonal agents to treat metastatic prostate cancer compared to standard treatment in people whose tumors have a  mutation in: BRCA1, BRCA2, ATM, BARD1, CDK12, PALB2, RAD51B, RAD51C, or RAD51D.

The following studies are enrolling people with advanced solid tumors, including prostate cancer: 

• NCT06545942: Treating Advanced Cancers with BRCA or Other Related Gene Mutations Using Targeted Therapy MOMA-313 Alone or In Combination with the PARP Inhibitor Olaparib. This trial will study MOMA-313 given alone or together with a PARP inhibitor (olaparib) in people with certain advanced or metastatic cancers with the following mutations: ATM, BRCA1, BRCA2, BRIP1, BARD1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, and/or RAD54L.
• NCT05932862: Study of a New InvestigationaI Inhibitor to Treat People with Advanced Solid Tumors. The study examines the safety and effectiveness of the investigational treatment XL309 when used alone or in combination with a PARP inhibitor to treat people with some advanced solid tumors, including prostate cancer. 
• NCT05417594: Study of the PARP inhibitor AZD9574 Alone and Combined with Other Cancer Medicines to Treat People with Advanced Solid Cancers (CERTIS1 Study). This study looks at a new PARP inhibitor AZD9574 given alone and in combination with other anti-cancer drugs for people with advanced cancer that has come back or progressed. 

Other clinical trials for people with prostate cancer can be found here.