Colorectal cancer in people with Lynch syndrome can include types of cancer found more typically in people without Lynch syndrome
https://www.facingourrisk.org/XRAY/colorectal-cancer-in-people-with-Lynch-syndrome
Full article: https://ascopubs.org/doi/abs/10.1200/PO.22.00675
When people with Lynch syndrome (LS) develop cancer, their tumors typically have a related set of features or biomarkers known as deficient mismatch repair (dMMR) and high microsatellite instability (MSI-High). However, occasionally people with Lynch syndrome have cancers that are proficient in mismatch repair (pMMR or MMR-P) and have microsatellite stability (MSS or MSI-Low) –more like the colorectal cancers found in people without Lynch syndrome. This study shows that 10 percent of people with Lynch syndrome may have these types of cancers. This can change treatment recommendations. (Posted 9/5/24)
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Questions To Ask Your Health Care Provider
- I have colorectal cancer; could I have Lynch syndrome?
- I have colorectal cancer; has my tumor been tested for mismatch repair deficiency (dMMR) or high microsatellite instability (MSI-High)?
- What is the best treatment for me based on my tumor biomarkers?
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.