Genes linked to aggressive prostate cancer
https://www.facingourrisk.org/XRAY/genes-linked-to-aggressive-prostate-cancer
Full article: https://jamanetwork.com/journals/jamaoncology/article-abstract/2809874
Previous research has linked some inherited mutations to prostate cancer risk. This study found a link to additional genes that should be added to prostate cancer gene panel tests. The study also looked at which genes were most closely linked to aggressive prostate cancer that is more likely to spread. (Posted 2/1/24)
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Questions To Ask Your Health Care Provider
- Should I have genetic testing with a prostate cancer gene panel?
- If testing is recommended, what genes are included with the test?
- Should I be tested for any other prostate cancer genes that are not included on the recommended prostate cancer gene panel?
- How will genetic test results impact my care and treatment?
Open Clinical Trials
The following are studies looking at ways to screen for prostate cancer in people at high risk:
- NCT03474913: Upright MRI for Prostate Cancer Screening. This study will compare the effectiveness of an upright magnetic resonance imaging (MRI) compared to prostate specific antigen (PSA) and current MRI imaging for prostate cancer screening.
- NCT05384535: Using a Shorter Type of MRI as a Screening Tool for People at High Risk for Prostate Cancer. This study is looking at whether using a faster type of MRI called bpMRI (biparametric MRI) will improve prostate cancer screening and lead to earlier detection of prostate cancer in high risk men.
- NCT05129605: Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS). This study investigates how enhanced prostate cancer screening using MRI improves early detection rates and provides further understanding of how inherited mutations can lead to the development of prostate cancer.
- NCT03805919: Men at High Genetic Risk for Prostate Cancer. This study use MRI to screen for prostate cancer in high-risk men. This study is open to men with an inherited mutation in BRCA1, BRCA2, HOX B13, ATM, NBN, TP53, MLH1, MSH2, MSH6, PMS2, EPCAM, CHECK2, PALB2, RAD51D, BRIP1 or FANCA.
- NCT04472338: Prostate Screening for Men With Inherited Risk of Developing Aggressive Prostate Cancer, PATROL Study. This study looks at ways to detect prostate cancer earlier in men who are at increased genetic risk of developing prostate cancer that forms, grows, or spreads quickly (aggressive). The study is open to men with mutations associated with prostate cancer risk.
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NCT05608694: MRI Screening in Men at High Risk of Developing Prostate Cancer. This study determines whether or not Magnetic Resonance Images (MRIs) identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.