Cancer patients with certain inherited mutations have cancer outcomes similar to those without inherited mutations

https://www.facingourrisk.org/XRAY/hereditary-cancer-and-cancer-mortality

Full article: https://ascopubs.org/doi/10.1200/JCO-24-02442

People with an inherited mutation in certain genes, including ATM, CHEK2, PALB2, BRCA or Lynch syndrome genes, have an increased risk of cancer. In this study, researchers wanted to know whether cancer patients with inherited mutations had a different chance of survival than patients without an inherited mutation in these genes. These results showed that, although the risk of cancer is increased, there is no difference in survival after a diagnosis of breast, pancreatic or colorectal cancer with or without these genetic changes. (posted 11/20/25)

Questions To Ask Your Health Care Provider

What does it mean to have a mutation (pathogenic variant) in a hereditary cancer gene?
Will this gene mutation change my treatment plan in any way?
How often should I be screened for other cancers related to my hereditary cancer mutation?
Am I eligible for any clinical trials?

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.