Can tumor tests identify more breast cancer patients who can safely skip chemotherapy?

Questions To Ask Your Health Care Provider

• What tumor tests have I had?
• How are my tumor test results being used to guide my treatment?
• Can I safely skip chemotherapy?
• With my tumor test results, what are the chances that my cancer will come back?

Open Clinical Trials

The following studies are enrolling people with early-stage ER-positive, HER2-negative breast cancer. 

• NCT03053193: MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles (FLEX). The FLEX Registry will be a large-scale, population-based, prospective registry. All patients with stage 1-3 breast cancer who receive MammaPrint and BluePrint testing on a primary breast tumor are eligible for this registry.
• NCT06401421: Looking at Tumor DNA Before Chemotherapy to Predict Cancer Recurrence in People with High-Risk, Early-Stage Breast Cancer. This is a study looking at biomarkers to predict recurrence in people with high-risk, early-stage breast cancer who are planning to undergo chemotherapy. 
• NCT05607004: (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/​HER2- Breast Cancer (EVANGELINE). This study looks at the drug (Z)-endoxifen as a possible treatment for pre-menopausal women with ER+/HER2- breast cancer. (Z)-endoxifen is a type of hormone therapy that blocks the body's natural estrogen from binding to cancer cells.
• NCT04567420: DNA-Guided Second Line Adjuvant Therapy For High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer. This study monitors people with early-stage, high-risk breast cancer for possible recurrence using a test called circulating tumor DNA (ctDNA). People who test positive for ctDNA but have no other signs of recurrence will receive either the drugs palbociclib combined with fulvestrant or standard-of-care adjuvant hormone therapy.

• NCT04852887: De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA). This study evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy. 

Several other clinical trials for patients with early-stage breast cancer can be found here.