Cancer risks of people with inherited PALB2 mutations

Questions To Ask Your Health Care Provider

• I have an inherited PALB2 mutation. What is my risk of cancer?
• Given my inherited PALB2 mutation, what preventive options should I consider?
• I have been diagnosed with cancer; does my mutation status alter treatment recommendations?
• I have a family history of cancer but I have not had genetic testing; should I consider genetic testing?
• How do I contact a genetic counselor?

Open Clinical Trials

The following are risk-management studies enrolling people with inherited mutations. Check study listings or contact the study team to see if you are eligible. 

Multiple cancers

• NCT02665195: Prospective Registry Of MultiPlex Testing (PROMPT). The goal of this online research PROMPT registry of people who have had genetic panel testing is to follow people with mutations or variants in genes on these panels, so that patients, physicians and researchers can more clearly understand these lesser-known risks. This study is open to people with an inherited mutation or VUS in sseveral different genes including ATM, BRIP1, CHEK2, PALB2, PTEN, RAD51C, RAD51D and others. 
• The Risk Factor Analysis of Hereditary Breast and Ovarian Cancer In Women with BRCA1, BRCA2 or PALB2 Mutations This study seeks to improve researchers’ understanding of how hormonal, reproductive and lifestyle factors may be associated with cancer in this high-risk population.

Prostate cancer

• NCT03805919: Men at High Genetic Risk for Prostate Cancer. This study uses MRI in high-risk men. This study is open to men with mutations in ATM, BRCA1, BRCA2, BRIP1, CHEK2, HOXB13, Lynch syndrome, NBN, RAD51D, TP53 and other genes.
• NCT05129605: Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS).  This study looks at the effectiveness of prostate MRI works as a screening tool for men at high risk for prostate cancer. This study is open to men with inherited mutations in ATM, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51C, RAD51D, TP53 and other genes. 

Ovarian cancer

• Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families: MicroRNA Detection Study (MiDE). The goal of this effort is to develop a test to detect ovarian cancer. This study is enrolling people with mutations in BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, Lynch syndrome and other genes. 
• NCT05287451: Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention. This study looks at the outcomes of women with inherited mutations in BRCA1, BRCA2, BRIP1, RAD51C and RAD51D who remove their fallopian tubes then remove their ovaries compared to women who undergo standard-of-care removal of their ovaries and fallopian tubes at the same time.

Pancreatic cancer

• NCT03250078: A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals. The main goal of this study is to screen and detect pancreatic cancer and precursor lesions in individuals with a strong family history or genetic predisposition to pancreatic cancer. MRI and Magnetic cholangiopancreatography (MRI/MRCP) will be utilized to screen for early-stage pancreatic lesions.
• NCT02206360: Pancreatic Cancer Early Detection Program. This pancreatic cancer screening study uses esophageal ultrasound to screen for pancreatic cancer in high-risk people. The study is open to people who have Lynch syndrome or an inherited mutation in ATM, BRCA1, BRCA2, CDKN2A, PALB2 or STK11. 
• NCT03568630: Blood Markers of Early Pancreas Cancer.  This pancreatic cancer study involves blood samples taken over time to lidentify biomarkers of pancreatic cancer in high-risk people. The study is open to people with a mutation linked to increased cancer risk.
• NCT02478892: Preliminary Evaluation of Screening for Pancreatic Cancer in Patients with an Inherited Genetic Risk Due to a BRCA1, BRCA2, PALB2 or ATM Mutation. This study uses MRI and endoscopic ultrasound to screen for pancreatic cancer in people with a BRCA1/2, PALB2 or ATM mutation. 

Additional risk-management clinical trials for people with inherited mutations may be found here.