Physical activity may prevent chemotherapy-related cognitive decline in women with breast cancer

Questions To Ask Your Health Care Provider

• I’ve been recently diagnosed with breast cancer. Will I benefit from increased physical activity?
• Should I exercise while receiving chemotherapy for breast cancer?
• What is the recommended amount of exercise for people undergoing chemotherapy?
• Should I report any cognitive changes during my chemotherapy treatment?
• Other than exercise, what else can I do to prevent chemotherapy-related cognitive decline?

Open Clinical Trials

The following studies are looking at management of side effects: 

Multiple cancers

• NCT02296450: Quality of Life (QoL) Assessment in Cancer Patients and Survivors With Dermatologic Conditions Using Dermatologic QoL Instruments. This large study is designed to see how skin conditions that are related to different kinds of cancer or cancer treatments affect a patient's overall well-being. 
• NCT05056077: Tools to be Fit. This is a quality of life study for people with bladder, breast, colon, endometrial, kidney (renal cell carcinoma), ovarian, prostate, or rectal cancer to figure out what tools work best for helping cancer survivors improve their diet and exercise.
• NCT03996265: Bupropion in Reducing Cancer Related Fatigue in Cancer Survivors. This will study how well the drug bupropion (welbutrin) reduces cancer-related fatigue in cancer survivors.

Breast cancer

• NCT04621721: Physical Activity at Home for Relief from Neuropathy Caused by Taxanes in People with Breast Cancer. This study will look at the effects of gain and balance training and resistance exercise (using bands) on gait, balance, and lower extremity muscle strength after a 16-week home-based exercise program compared to educational materials without an exercise program.
• NCT04586530: Telehealth and Memory Study (TAMS). The overall purpose of this trial is to confirm the effectiveness of Memory and Attention Adaptation Training (a cognitive-behavioral therapy) as a treatment for chemotherapy-related cognitive dysfunction among breast cancer survivors.
• NCT02290834: Chemotherapy-induced cognitive and brain changes in older adults with breast cancer. The study will investigate cognitive abilities and brain images before and after chemotherapy to identify people at risk for cognitive side effects and to better understand the effects of treatment on brain structure and function.
• NCT04906200: Web-Based Symptom Monitoring and Self-Management Portal for Adolescent and Young Adult Breast Cancer Survivors.  This compares a web-based patient-reported symptom-monitoring and self-management portal to standard therapy in young breast cancer survivors. 
• NCT04837820: The Effect of Acupuncture on Cancer-Related Cognitive Difficulties. This study will test whether acupuncture can improve thinking and insomnia in breast cancer survivors. This study will also look at insomnia's link to cognitive difficulties.
• NCT03879629: TrAstuzumab Cardiomyopathy Therapeutic Intervention With Carvedilol (TACTIC). Breast cancer patients receiving Herceptin or other HER2-directed therapy are at risk of heart damage. This study is looking at whether beta-blocker drugs could help prevent this from happening.   

Colorectal cancer

• NCT05239338: Preserving Fertility After Colorectal Cancer Study (PREFACE). The PREFACE Study is a study of reproductive health and clinical outcomes among individuals diagnosed with colorectal cancer between age 18 to 49 years.
• NCT06420726: Resistance Exercise and Creatine in Colorectal Cancer. This study aims to assess the feasibilty of combining creatine supplementation with resistance training versus resistance training alone in colorectal cancer survivors. 

Ovarian cancer

• NCT04533763: Living WELL: A Web-Based Program for Ovarian Cancer Survivors. This studies a group-based and web-delivered tool for ovarian cancer survivors in increasing quality of life and decreasing stress, depressive mood, anxiety, and fatigue across a 12-month period.
• NCT05047926: Prehabilitation for Advanced Ovarian Cancer Patients. Prehabilitation may improve peri-operative outcomes in patients undergoing cancer surgery. This study will look at structured activity for women undergoing neoadjuvant chemotherapy to improve their physical state prior to surgical intervention and thus improve outcomes.

Prostate cancer

• NCT03971591: Men Moving Forward: A Lifestyle Program for African-American Prostate Cancer Survivors (MMF).  This study will look at Men Moving Forward (MMF), a community-based lifestyle intervention that supports adherence to nutrition and physical activity guidelines to promote improved body composition and lessen the side effects of treatment.
• NCT05155501: Pelvic Fascia spARing Radical Prostatectomy TrIAL (PARTIAL).  This clinical trial is studying whether pelvic fascia-sparing radical prostatectomy has similar cancer control and sexual function outcomes; and significantly better urinary function, less penile deformity and inguinal hernia risks as compared to radical prostatectomy.

The following studies focus on exercise for people diagnosed with breast cancer. 

• NCT04000880: AMPLIFY: An Online Weight Loss Study Specifically for Cancer Survivors. AMPLIFY is a nationwide, web-based diet and exercise study recruiting overweight survivors of early-stage breast, prostate, ovarian, renal, colorectal, endometrial cancer or multiple myeloma. Participants are age 50 and older and are interested in becoming more active, eating better and losing weight.
• NCT04621721: Physical Activity at Home for Relief from Neuropathy Caused by Taxanes in People with Breast Cancer. This study looks at the effects of gain and balance training and resistance exercise (using bands) on gait, balance and lower extremity muscle strength after a 16-week, home-based exercise program compared to educational materials without an exercise program.
• NCT04298086: A Study of the Body's Response to Exercise and a Plant-Based Diet in Overweight Postmenopausal Women With Breast Cancer. This study is looking to find out what effects exercise and a plant-based diet have on aromatase levels in postmenopausal women who are overweight and being treated with an aromatase inhibitor for their HR+ breast cancer. 
• NCT05327452: Testing Home-based Exercise Strategies in Underserved Minority Cancer Patients Undergoing Chemotherapy: the THRIVE Study. The purpose of this research is to determine whether a 16-week, home-based, aerobic and resistance exercise intervention increases physical activity levels in Black and Hispanic patients with breast, colorectal, or prostate cancer.
• NCT03761706: Impact of Home-based Aerobic and Strength Exercises During Chemotherapy for Early Breast Cancer on Biomarkers of Aging. This effort determines if engagement in physical activity during chemotherapy has a moderating effect on increases in p16 levels during chemotherapy.
• NCT03824145: Every Day Counts: A Lifestyle Program for Women With Metastatic Breast Cancer (EDC).This study examines dietary and activity patterns, body composition, blood and quality of life in breast cancer patients. The study will recruit 176 women with MBC in Milwaukee and Chicago.

Visit our Featured Research Page and Research Search and Enroll Tool to find additional studies enrolling people with, or at high risk for cancer.