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A new method for determining whether genetic variants in BRCA1 increase cancer risk

https://www.facingourrisk.org/XRAY/classifying-uncertain-variants
Full article: http://www.ncbi.nlm.nih.gov/pubmed/30209399

Ever since BRCA1 was discovered, researchers have been trying to understand which of the thousands of possible DNA changes in this gene increase cancer risk and which are harmless changes.  A new study in Nature reports how a cutting-edge technology called “genome editing” may be used to classify changes—known as variants of uncertain significance-in BRCA1 as harmful or harmless. Once validated, this same technology may be used to classify variants in other genes. (9/29/18)

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