FDA allows testing of a vaccine designed to prevent breast cancer
https://www.facingourrisk.org/XRAY/vaccine-to-prevent-breast-cancer
Full article: https://ir.anixa.com/press-releases/detail/962/anixa-biosciences-and-cleveland-clinic-announce-fda
Scientists have been working for many years to develop a vaccine that will prevent breast cancer. The FDA recently announced that the first clinical trial to test a preventive breast cancer vaccine can begin. This vaccine is the result of over a decade of research in animals and human cells. While researchers will first test the vaccine in women who have breast cancer, they hope to use this vaccine in the future to prevent breast cancer. (posted 5/25/21)
THIS INFORMATION HAS BEEN UPDATED on 10/12/2021: The clinical trial discussed in this XRAY review has begun recruiting participants. Researchers hope to enroll 24 patients with non-metastatic triple-negative breast cancer. The trial is being conducted at the Cleveland Clinic in Cleveland, Ohio. More information on this trial can be found here.
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Questions To Ask Your Health Care Provider
- Are any clinical trials of vaccines to treat breast cancer right for me?
- What is my stage of cancer?
- Am I considered at high risk for a recurrence of my cancer?
- Are any available targeted treatments such as immunotherapies right for me?
Open Clinical Trials
The following are studies enrolling people with early-stage, TNBC.
- NCT05629585: A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03). The study will look at how safe and effective the investigational drug Dato-DXd is with or without durvalumab when compared with the combination capecitabine and/or pembrolizumab in people with stage I to III TNBC who have residual invasive disease in the breast and/or axillary lymph nodes at surgical resection following neoadjuvant systemic therapy.
- NCT04584255: Treating Early-Stage BRCA, or PALB2-Associated Breast Cancer with a PARP Inhibitor (Niraparib) and Immunotherapy (Dostarlimab). This research study involves pre-operative therapy that is specifically targeted for breast cancer in individuals with BRCA mutations.
- NCT04674306: Adjuvant Therapy With an Alpha-lactalbumin Vaccine in Triple-Negative Breast Cancer. The purpose of this study is to determine the safety as well as the most effective dose of the alpha-lactalbumin vaccine (aLA breast cancer vaccine) to treat patients with non-metastatic triple negative breast cancer.
- NCT03562637: Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC. The GLORIA study is a Phase III, randomized trial looking at the use of the drug adagloxad simolenin (OBI-822) in combination with the drug OBI-821 in the adjuvant treatment of patients with high-risk early-stage TNBC.
- NCT05455658: STEMVAC in Patients With Early Stage Triple Negative Breast Cancer. This trial studies the effect of a vaccine (STEMVAC) to treat patients with patients with stage IB-III triple negative breast cancer.
- NCT05929768: Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer. This study compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer.
A number of other clinical trials for patients with early-stage TNBC can be found here.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.