Chemotherapy, Bevacizumab, and/or Atezolizumab for Patients With Deficient DNA Mismatch Repair (dMMR or MSI-H) Metastatic Colorectal Cancer, the COMMIT Study
https://www.facingourrisk.org/research-clinical-trials/study/126/chemotherapy-bevacizumab-andor-atezolizumab-for-dmmr-msi-h-metastatic-colorectal-cancer-commit-study
Clinicaltrials.gov identifier:
NCT02997228 (https://clinicaltrials.gov/show/NCT02997228)
Treatment
This is a treatment study is for people with metastatic colorectal cancer
Study Contact Information:
For additional information, please contact:
Principal Investigator: Caio Max S Rocha Lima at NRG Oncology by phone: 336-713-6771 or by email
About the Study
This study is for people with metastatic colorectal cancer. The study will compare how well treatment with a combination of chemotherapy agents and an immunotherapy agent works compared with treatment using an immunotherapy agent alone. This study is focused on patients who are determined to be mismatch-repair deficient (dMMR) or have an MSI-H diagnosis, which are commonly seen in people with Lynch syndrome.
Type of Study
The study is an open-label, Phase III, randomized study.
There are two remaining treatment groups in this study. One group will receive combination chemotherapy along with the immunotherapy drug atezolizumab. The other group will receive immunotherapy drug atezolizumab alone. (A third study group who were to receive combination chemotherapy alone is no longer accepting new patients.)
The study is randomized; participants will be placed into one of the two study groups by chance.
The study is open-label. All participating patients will know which of the two groups they have been assigned to and which treatments they are being given.
What the Study Entails
Patients will be assigned randomly to either Group 2 or Group 3.
- Group 1: Chemotherapy Only - This study group is closed
- Group 2: Immunotherapy Only
- Patients receive the immunotherapy atezolizumab IV over 30-60 minutes on day 1.
- Treatment repeats every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity.
- Group 3: Chemotherapy and Immunotherapy
- Patients receive atezolizumab IV over 30-60 minutes on day 1. Treatment repeats every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity.
- Patients also receive combination chemotherapy intravenously (bevacizumab oxaliplatin, leucovorin calcium and fluorouracil) starting on day 1. Treatment with oxaliplatin repeats every 2 weeks for up to 10 cycles in the absence of disease progression or unacceptable toxicity. Cycles of bevacizumab, leucovorin calcium, and fluorouracil repeat every 2 weeks in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 8 weeks for 18 months, and then every 12 weeks for up to 5 years.
Study Sites
| Arkansas | California | Colorado |
| Connecticut | Delaware | District of Columbia |
| Florida | Georgia | Idaho |
| Illinios | Indiana | Iowa |
| Kansas | Kentucky | Louisiana |
| Maine | Maryland | Michigan |
| Minnesota | Mississippi | Missouri |
| Montana | Nebraska | Nevada |
| New Hampshire | New Jersey | New Mexico |
| New York | North Carolina | North Dakota |
| Ohio | Oklahoma | Oregon |
| Pennsylvania | South Carolina | South Dakota |
| Tennessee | Texas | Utah |
| Vermont | Virginia | Washington |
| West Virginia | Wisconsin | Wyoming |
- Jonesboro: Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Contact: Emily Carvell by phone: 870-936-7066 or by email.
- Anaheim: Kaiser Permanente-Anaheim
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Baldwin Park: Kaiser Permanente-Baldwin Park
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Bellflower: Kaiser Permanente-Bellflower
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email. - Berkeley: Alta Bates Summit Medical Center-Herrick Campus
Contact: Site Contact by phone 415-209-2686 or by email.
Principal Investigator: Kristie A. Bobolis - Fontana: Kaiser Permanente-Fontana
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Harbor City: Kaiser Permanente - Harbor City
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Irvine: Kaiser Permanente-Irvine
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Los Angeles: Kaiser Permanente Los Angeles Medical Center
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Marysville: Fremont - Rideout Cancer Center
Contact: Site Contact by phone: 530-749-4400
Principal Investigator: Edward J. Kim - Modesto: Memorial Medical Center
Contact: Site Contact by phone 415-209-2686 or by email.
Principal Investigator: Kristie A. Bobolis - Ontario: Kaiser Permanente-Ontario
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Orange: Saint Joseph Hospital - Orange
Contact: Site Contact by phone: 714-734-6220
Principal Investigator: Timothy E. Byun - Irvine: UC Irvine Health/Chao Family Comprehensive Cancer Center
Study Contact: by phone at 877-827-8839 or by email.
Principal Investigator: Fa-Chyi Lee - Panorama City: Kaiser Permanente - Panorama City
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Riverside: Kaiser Permanente-Riverside
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Sacramento: University of California Davis Comprehensive Cancer Center
Site Contact: by phone: 916-734-3089
Principal Investigator: Edward J. Kim - San Diego: Kaiser Permanente-San Diego Mission
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - San Diego: Kaiser Permanente-San Diego Zion
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - San Marcos: Kaiser Permanente-San Marcos
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher - Whittier:Presbyterian Intercommunity Hospital
Contact: Site Public Contact 562-698-0811
Principal Investigator: Lisa S. Wang - Woodland Hills: Kaiser Permanente-Woodland Hills
Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.
Principal Investigator: Gary L. Buchschacher
- Aurora: Rocky Mountain Cancer Centers-Aurora
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Aurora: University of Colorado Hospital
Contact: Site Public Contact 720-848-0650
Principal Investigator: Alexis D. Leal - Boulder: Rocky Mountain Cancer Centers-Boulder
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Colorado Springs: Penrose-Saint Francis Healthcare
Contact: Site Public Contact by phone 308-398-6518 or by email.
Principal Investigator: Richard L. Deming - Colorado Springs: UCHealth Memorial Hospital Central
Contact: Site Public Contact by phone: 719-365-2406
Principal Investigator: Alexis D. Leal - Colorado Springs: Memorial Hospital North
Contact: Site Public Contact by phone: 719-365-2406
Principal Investigator: Alexis D. Leal - Denver: National Jewish Health-Main Campus
Contact: Site Public Contact by phone 877-225-5654 or by email.
Principal Investigator: Nicholas DiBella - Denver: Boulder: Rocky Mountain Cancer Centers-Midtown
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Denver: Boulder: Rocky Mountain Cancer Centers-Rose
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Englewood: Mountain Blue Cancer Care Center - Swedish
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Swedish Medical Center
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Fort Collins:Poudre Valley Hospital
Contact: Site Public Contact 970-297-6150
Principal Investigator: Alexis D. Leal - Fort Collins: Cancer Care and Hematology-Fort Collins
Contact: Site Public Contact by phone 412-339-5294 or by email.
Principal Investigator: Alexis D. Leal - Golden: National Jewish Health-Western Hematology Oncology
Contact: Site Public Contact by phone 877-225-5654 or by email.
Principal Investigator: Nicholas DiBella - Greeley: North Colorado Medical Center
Contact: Site Contact at: 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Greeley: UCHealth Greeley Hospital
Contact: Site Public Contact by phone 412-339-5294 or by email.
Principal Investigator: Alexis D. Leal - Littleton: Rocky Mountain Cancer Centers-Littleton
Contact: Site Public Contact by phone 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Lone Tree: Rocky Mountain Cancer Centers-Sky Ridge
Contact: Site Public Contact by phone 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Loveland: Medical Center of the Rockies
Contact: Site Public Contact 970-203-7083
Principal Investigator: Alexis D. Leal - Loveland: McKee Medical Center
Contact: Site Public Contact by phone 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella - Thornton: National Jewish Health-Northern Hematology Oncology
Contact: Site Public Contact by phone 303-777-2663 or by email.
Principal Investigator: Nicholas DiBella
- Danbury: Danbury Hospital
Contact: Site Public Contact 203-739-8074
Principal Investigator: Wenli Gao - Hartford: Hartford Hospital
Contact: Site Public Contact 860-545-5363 - Principal Investigator: Gerard Fumo
- Newark: Helen F Graham Cancer Center
Contact: Site Public Contact by phone 302-623-4450 or by email.
Principal Investigator: Gregory A. Masters - Newark: Medical Oncology Hematology Consultants PA
Contact: Site Public Contact by phone 302-623-4450 or by email.
Principal Investigator: Gregory A. Masters - Rehoboth Beach: Beebe Health Campus
Contact: Site Public Contact 302-645-3100 or by email.
Principal Investigator: Gregory A. Masters
- Kaiser Permanente-Capitol Hill Medical Center
Contact: Site Public Contact 301-548-5743
Principal Investigator: Leon C. Hwang
- Fort Myers: Regional Cancer Center-Lee Memorial Health System
Contact: Site Public Contact 412-339-5294 Roster@nrgoncology.org
Principal Investigator: Paul M. Bloomston - Gainesville: University of Florida Health Science Center - Gainesville
Contact: Site Public Contact 352-273-8010 or by email.
Principal Investigator: Thomas J. George - Orlando: AdventHealth Orlando
Contact: Site Public Contact 407-303-2090 or by email.
Principal Investigator: Mohamedtaki A. Tejani
- Albany: Phoebe Putney Memorial Hospital
Contact: Site Public Contact 229-312-0405 or by email.
Principal Investigator: Sharad A. Ghamande - Athens: University Cancer and Blood Center LLC
Contact: Site Public Contact by phone 706-353-5006 or by email.
Principal Investigator: Sharad A. Ghamande - Augusta: Augusta Oncology Associates PC-D'Antignac
Contact: Site Public Contact 706-821-2944
Principal Investigator: Sharad A. Ghamande - Augusta: Augusta Oncology Associates PC-Wheeler
Contact: Site Public Contact 706-736-1830
Principal Investigator: Sharad A. Ghamande - Augusta: Augusta University Medical Center
Contact: Site Public Contact by phone 706-721-2388 or by email.
Principal Investigator: Sharad A. Ghamande - Newnan: CTCA at Southeastern Regional Medical Center
Contact: Site Public Contact 770-400-6629
Principal Investigator: Eyal Meiri
- Boise: Saint Alphonsus Cancer Care Center-Boise
Contact: Site Public Contact 734-712-3671 or by email.
Principal Investigator: John M. Schallenkamp - Boise: Saint Luke's Cancer Institute - Boise
Contact: Site Public Contact 208-381-2774 or by email .
Principal Investigator: Krishna C. Alluri - Caldwell: Saint Alphonsus Cancer Care Center-Caldwell; Contact: 734-712-3671 or email
- Coeur d'Alene: Kootenai Medical Center; Contact: 406-969-6060 or email
- Fruitland: Saint Luke's Cancer Institute - Fruitland; Contact: 208-381-2774 or email
- Meridian: Saint Luke's Cancer Institute - Meridian; Contact: 208-381-2774 or email
- Nampa: Saint Alphonsus Medical Center-Nampa; Contact: 734-712-3671 or email
- Nampa: Saint Luke's Cancer Institute - Nampa; Contact: 208-381-2774 or email
- Post Falls: Kootenai Cancer Center; Contact: 406-969-6060 or email
- Sandpoint: Kootenai Cancer Center; Contact: 406-969-6060 or email
- Twin Falls:Saint Luke's Cancer Institute - Twin Falls; Contact: 208-381-2774 or email
- Bloomington: Illinois CancerCare-Bloomington; Contact: 309-243-3605 or email
- Canton: Illinois CancerCare-Canton; Contact: 309-243-3605 or email
- Carterville: SIH Cancer Institute; Contact: 618-985-3333 or email
- Carthage: Illinois CancerCare-Carthage; Contact: 309-243-3605 or email
- Chicago: Rush University Medical Center; Contact : 312-942-5498 or email
- Chicago: University of Illinois, Chicago; Contact: 312-355-3046
- Danville: Carle on Vermilion: Contact: 800-446-5532 or by email
- Decatur: Cancer Care Specialists of Illinois - Decatur; Contact: 217-876-4740 or email
- Dixon: Illinois CancerCare-Dixon; Contact 815-285-7800
- Effingham: Carle Physician Group-Effingham 800-446-5532 or by email
- Effingham: Crossroads Cancer Center; Contact: 217-876-4740 or by email
- Eureka: Illinois CancerCare-Eureka; Contact 309-243-3605 or email
- Evanston: NorthShore University HealthSystem-Evanston Hospital; Contact: 847-570-2109
- Galesburg: Illinois CancerCare-Galesburg; Contact: 309-243-3605 or email
- Glenview: NorthShore University HealthSystem-Glenbrook Hospital; Contact: 847-570-2109
- Harvey:Ingalls Memorial Hospital; Contact: 708-915-4673 clinicaltrials@ingalls.org
- Highland Park: NorthShore University HealthSystem-Highland Park Hospital: Contact: 847-570-2109
- Kewanee: Illinois CancerCare-Kewanee Clinic; Contact: 309-243-3605 or email
- Macomb: Illinois CancerCare-Macomb; Contact: 309-243-3605 or email
- Mattoon: Carle Physician Group-Mattoon/Charleston: 800-446-5532 or by email
- Maywood: Loyola University Medical Center; Contact: 708-226-4357
- Mount Vernon: Good Samaritan Regional Health Center; Contact: 618-242-4600
- O'Fallon: Cancer Care Center of O'Fallon; Contact 217-876-4762 or by email
- Ottawa: Illinois CancerCare-Ottawa Clinic; Contact: 309-243-3605 or by email
- Pekin: Illinois CancerCare-Pekin; Contact: 309-243-3605 or by email
- Peoria: Illinois CancerCare-Peoria; Contact: 309-243-3605 or by email
- Peru: Illinois CancerCare-Peru; Contact: 309-243-3605 or by email
- Princeton: Illinois CancerCare-Princeton; Contact: 309-243-3605 or by email
- Silvis: Genesis Cancer Center - Silvis; Contact: 563-421-1908 or by email
- Springfield: Southern Illinois University School of Medicine; Contact: 217-545-7929
- Springfield: Springfield Clinic; Contact: 800-444-7541
- Urbana: Carle Cancer Center; Contact: 800-446-5532 or by email
- Indianapolis: Franciscan Health Indianapolis; Contact: 317-528-7060
- Mooresville: Franciscan Health Mooresville; Contact: 317-834-3603
- Bettendorf: University of Iowa Healthcare Cancer Services Quad Cities; Contact: 563-355-7733 or by email
- Cedar Rapids: Mercy Hospital; Contact: 319-365-4673
- Cedar Rapids: Oncology Associates at Mercy Medical Center; Contact 319-363-2690
- Clive: Medical Oncology and Hematology Associates-West Des Moines; Contact: 308-398-6518 or by email
- Clive: Mercy Cancer Center-West Lakes; Contact: 308-398-6518 or by email
- Des Moines: Medical Oncology and Hematology Associates-Des Moines; Contact: 515-282-2921
- Des Moines: Broadlawns Medical Center; Contact: 515-282-2200
- Des Moines: Medical Oncology and Hematology Associates-Laurel; Contact: 308-398-6518 or by email
- Des Moines: Mercy Medical Center - Des Moines; Contact: 308-398-6518 or by email
- Fort Dodge: McFarland Clinic PC-Trinity Cancer Center; Contact : 515-574-8302
- Iowa City: University of Iowa/Holden Comprehensive Cancer Center; Contact: 800-237-1225
- West Des Moines: Mercy Medical Center-West Lakes; Contact: 308-398-6518 or by email
- Hays: HaysMed University of Kansas Health System; 785-623-5774
- Lawrence: Lawrence Memorial Hospital; Contact: 785-505-2800 or by email
- Olathe: Olathe Health Cancer Center; Contact: 913-355-8000 or by email
- Salina: Salina Regional Health Center; Contact: 785-452-7038 or by email
- Topeka: University of Kansas Health System Saint Francis Campus; Contact: 785-295-8000
- Westwood: University of Kansas Hospital-Westwood Cancer Center; Contact: 913-588-3671 or by email
- Wichita: Cancer Center of Kansas-Wichita Medical Arts Tower; Contact: 316-268-5374 or by email
- Lexington: Baptist Health Lexington; Contact: 859-260-6425
- Lexington: Saint Joseph Hospital East; Contact: 308-398-6518 or by email
- Lexington: University of Kentucky/Markey Cancer Center; Contact: 859-257-3379
- Kenner: Ochsner Medical Center Kenner; Contact: 504-464-8314 or by email
- New Orleans: Ochsner Medical Center Jefferson; Contact: 504-703-8712 or by email
- Augusta: Harold Alfond Center for Cancer Care; Contact: 207-626-4855
- Bangor: Eastern Maine Medical Center; Contact 207-973-4274
- Biddeford: MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford; Contact by email
- Brewer: Lafayette Family Cancer Center-EMMC; Contact: 800-987-3005
- Sanford: MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford; Contact by email
- South Portland: Maine Medical Partners - South Portland; Contact: 207-396-8670 or by email
- Baltimore: Kaiser Permanente-Woodlawn Medical Center; Contact: 301-816-7218
- Easton: University of Maryland Shore Medical Center at Easton; Contact: 410-822-1000 or by email
- Gaithersburg: Kaiser Permanente-Gaithersburg Medical Center; Contact: 301-816-7218
- Largo: Kaiser Permanente - Largo Medical Center; Contact: 301-816-7446
- Boston: Dana-Farber Cancer Institute; Contact: 877-442-3324
- Ann Arbor: Saint Joseph Mercy Hospital; Contact: 734-712-3671 or by email
- Bay City: McLaren Cancer Institute-Bay City; Contact: 313-576-9790 or by email
- Bloomfield: McLaren Cancer Institute-Bloomfield; Contact: 313-576-9790 or by email
- Brighton: IHA Hematology Oncology Consultants-Brighton; Contact: 734-712-3671 or by email
- Brighton: Saint Joseph Mercy Brighton; Contact: 734-712-3671 or by email
- Brownstown: Henry Ford Cancer Institute-Downriver; Contact: 313-916-3721 or by email
- Canton: IHA Hematology Oncology Consultants-Canton; Contact: 734-712-3671 or by email
- Canton: Saint Joseph Mercy Canton; Contact: 734-712-3671 or by email
- Chelsea: IHA Hematology Oncology Consultants-Chelsea; Contact: 734-712-3671 or by email
- Chelsea: Saint Joseph Mercy Chelsea; Contact: 734-712-3671 or by email
- Clarkston: Hematology Oncology Consultants-Clarkston; Contact: 734-712-3671 or by email
- Clarkston: McLaren Cancer Institute-Clarkston; Contact: 313-576-9790 or by email
- Clinton Township: Henry Ford Macomb Hospital-Clinton Township; Contact: 313-916-3721 or by email
- Dearborn: Henry Ford Medical Center-Fairlane; Contact: 313-916-3721 or by email
- Detroit:Wayne State University/Karmanos Cancer Institute; Contact: 313-576-9790 or by email
- Detroit: Henry Ford Hospital; Contact: 313-916-3721 or by email
- Farmington Hills: Weisberg Cancer Treatment Center; Contact: 313-576-9790 or by email
- Flint: McLaren Cancer Institute-Flint; ; Contact: 313-576-9790 or by email
- Flint: Singh and Arora Hematology Oncology PC; Contact: 313-576-9790 or by email
- Grand Rapids: Spectrum Health at Butterworth Campus; Contact: 616-391-1230 or by email
- Jackson: Allegiance Health; Contact: 313-916-3721 or by email
- Kalamazoo: West Michigan Cancer Center; Contact: 616-391-1230 or by email
- Lansing: McLaren-Greater Lansing; Contact: 313-576-9790 or by email
- Lansing: Sparrow Hospital; Contact: 734-712-3671 or by email
- Lapeer: McLaren Cancer Institute-Lapeer Region; Contact: 313-576-9790 or by email
- Livonia: Hope Cancer Clinic; Contact: 734-712-3671 or by email
- Livonia: Saint Mary Mercy Hospital; Contact: 734-712-3671 or by email
- Mount Clemens: McLaren Cancer Institute-Macomb; Contact: 313-576-9790 or by email
- Mount Pleasant: McLaren Cancer Institute-Central Michigan; Contact: 313-576-9790 or by email
- Novi: Henry Ford Medical Center-Columbus; Contact: 313-916-3721 or by email
- Petoskey: McLaren Cancer Institute-Northern Michigan; Contact: 313-576-9790 or by email
- Pontiac: Newland Medical Associates-Pontiac; Contact: 734-712-3671 or by email
- Pontiac: Saint Joseph Mercy Oakland; Contact: 734-712-3671 or by email
- Port Huron: McLaren-Port Huron; Contact: 313-576-9790 or by email
- Saginaw: Ascension Saint Mary's Hospital; Contact: 734-712-3671 or by email
- Saginaw: Oncology Hematology Associates of Saginaw Valley PC; Contact: 734-712-3671 or by email
- Tawas City: Ascension Saint Joseph Hospital; Contact: 734-712-3671 or by email
- Traverse City: Munson Medical Center; Contact: 616-391-1230 or by email
- West Bloomfield: Henry Ford West Bloomfield Hospital; Contact: 313-916-3721 or by email
- West Branch: Saint Mary's Oncology/Hematology Associates of West Branch; Contact: 734-712-3671 or by email
- Ypsilanti: IHA Hematology Oncology Consultants-Ann Arbor; Contact: 734-712-3671 or by email
- Bemidji: Sanford Joe Lueken Cancer Center; Contact: 218-333-5000 or by email
- Burnsville: Fairview Ridges Hospital; Contact: 952-993-1517 or by email
- Coon Rapids: Mercy Hospital; Contact: 952-993-1517 or by email
- Deer River: Essentia Health - Deer River Clinic; Contact: 218-786-3308 or by email
- Duluth: Essentia Health Cancer Center; Contact: 218-786-3308 or by email
- Hibbing: Essentia Health Hibbing Clinic; Contact: 218-786-3308 or by email
- Maplewood: Minnesota Oncology Hematology PA-Maplewood; Contact: 952-993-1517 or by email
- Minneapolis: Health Partners; Contact: 952-993-1517 or by email
- Saint Paul: Regions Hospital; Contact: 952-993-1517 or by email
- Virginia: Essentia Health Virginia Clinic; Contact: 218-786-3308 or by email
- Grenada: Baptist Cancer Center-Grenada; Contact: 901-226-1366 or by email
- New Albany: Baptist Memorial Hospital and Cancer Center-Union County; Contact: 901-226-1366 or by email
- Oxford: Baptist Memorial Hospital and Cancer Center-Oxford; Contact: 901-226-1366 or by email
- Southhaven: Baptist Memorial Hospital and Cancer Center-Desoto
- Ballwin: Saint Louis Cancer and Breast Institute-Ballwin; Contact: 314-251-7058
- Cape Girardeau: Saint Francis Medical Center; Contact: 573-334-2230 sfmc@sfmc.net
- Joplin: Mercy Hospital Joplin; Contact: 417-556-3074 esmeralda.carrillo@mercy.net
- Kansas City: Truman Medical Centers; Contact: 816-404-4375
- Saint Louis: Saint Louis Cancer and Breast Institute-South City; Contact: 314-353-1870
- Saint Louis: Mercy Hospital Saint Louis; Contact: 314-251-7066
- Anaconda: Community Hospital of Anaconda; Contact: 406-969-6060 mccinfo@mtcancer.org
- Billings: Billings Clinic Cancer Center; Contact: 800-996-2663 research@billingsclinic.org
- Bozeman: Bozeman Deaconess Hospital Contact: 406-969-6060 mccinfo@mtcancer.org
- Great Falls: Benefis Healthcare- Sletten Cancer Institute; Contact: 406-969-6060 mccinfo@mtcancer.org
- Kalispell: Kalispell Regional Medical Center; Contact 406-969-6060 mccinfo@mtcancer.org
- Missoula, Community Medical Hospital; Contact 406-969-6060 mccinfo@mtcancer.org
Nebraska Methodist Hospital
Omaha, Nebraska
Contact: Site Public Contact 402-354-5144
Principal Investigator: Timothy Huyck
OptumCare Cancer Care at Seven Hills
Henderson, Nevada
Contact: Site Public Contact 702-384-0013 research@sncrf.org
Principal Investigator: John A. Ellerton
OptumCare Cancer Care at Oakey
Las Vegas, Nevada
Contact: Site Public Contact 702-384-0013 research@sncrf.org
Principal Investigator: John A. Ellerton
OptumCare Cancer Care at MountainView
Las Vegas, Nevada
Contact: Site Public Contact 702-384-0013 research@sncrf.org
Principal Investigator: John A. Ellerton
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada
Contact: Site Public Contact 702-384-0013 research@sncrf.org
Principal Investigator: John A. Ellerton
Renown Regional Medical Center
Reno, Nevada
Contact: Site Public Contact 702-384-0013 research@sncrf.org
Principal Investigator: John A. Ellerton
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire
Contact: Site Public Contact 800-639-6918 cancer.research.nurse@dartmouth.edu
Principal Investigator: Kathryn C. Hourdequin
Norris Cotton Cancer Center-Manchester
Manchester, New Hampshire
Contact: Site Public Contact 603-629-1828
Principal Investigator: Kathryn C. Hourdequin
Norris Cotton Cancer Center-Nashua
Nashua, New Hampshire
Contact: Site Public Contact 603-577-4282 Laura.A.Menken@hitchcock.org
Principal Investigator: Kathryn C. Hourdequin
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey
Contact: Site Public Contact 609-631-6946
Principal Investigator: Howard S. Hochster
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey
Contact: Site Public Contact 732-235-7356
Principal Investigator: Howard S. Hochster
The Valley Hospital-Luckow Pavilion
Paramus, New Jersey
Contact: Site Public Contact 201-634-5792
Principal Investigator: Kevin C. Wood
Valley Hospital
Ridgewood, New Jersey
Contact: Site Public Contact 201-634-5792 cparish@valleyhealth.com
Principal Investigator: Kevin C. Wood
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey
Contact: Site Public Contact 908-685-2481 Siby.Varughese@rwjbh.org
Principal Investigator: Beiqing Pan
University of New Mexico Cancer Center
Albuquerque, New Mexico
Contact: Site Public Contact 505-925-0366 LByatt@nmcca.org
Principal Investigator: Jessica Belmonte
Presbyterian Kaseman Hospital
Albuquerque, New Mexico
Contact: Site Public Contact 505-559-6113 WBurman@phs.org
Principal Investigator: Jessica Belmonte
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico
Contact: Site Public Contact 575-556-6545 Kim.Hoffman@lpnt.net
Principal Investigator: Jessica Belmonte
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico
Contact: Site Public Contact 505-559-6113 WBurman@phs.org
Principal Investigator: Jessica Belmonte
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York
Contact: Site Public Contact 607-271-7000
Principal Investigator: Serge Dauphin
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York
Contact: Site Public Contact 212-263-4434 prmc.coordinator@nyumc.org
Principal Investigator: Daniel J. Becker
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina
Contact: Site Public Contact 877-668-0683 cancerclinicaltrials@med.unc.edu
Principal Investigator: Hanna K. Sanoff
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina
Contact: Site Public Contact 919-587-9084 jfields@cancersmoc.com
Principal Investigator: Samer S. Kasbari
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina
Contact: Site Public Contact 919-587-9084 jfields@cancersmoc.com
Principal Investigator: Samer S. Kasbari
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina
Contact: Site Public Contact 828-696-4716 karen.morris@unchealth.unc.edu
Principal Investigator: James E. Radford
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina
Contact: Site Public Contact 910-587-9084 jfields@cancersmoc.com
Principal Investigator: Samer S. Kasbari
Vidant Oncology-Kenansville
Kenansville, North Carolina
Contact: Site Public Contact 252-559-2201 Carla.Zimmerman@vidanthealth.com
Principal Investigator: Misbah U. Qadir
Vidant Oncology-Kinston
Kinston, North Carolina
Contact: Site Public Contact 252-559-2201 Carla.Zimmerman@vidanthealth.com
Principal Investigator: Misbah U. Qadir
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina
Contact: Site Public Contact 910-715-3500 jcwilliams@firsthealth.org
Principal Investigator: Charles S. Kuzma
Wake Forest University Health Sciences
Winston-Salem, North Carolina
Contact: Site Public Contact 336-713-6771
Principal Investigator: Caio Max S. Rocha Lima
Sanford Bismarck Medical Center
Bismarck, North Dakota
Contact: Site Public Contact 701-323-5760 OncologyClinicalTrialsFargo@sanfordhealth.org
Principal Investigator: Preston D. Steen
Sanford Broadway Medical Center
Fargo, North Dakota
Contact: Site Public Contact 701-323-5760 OncologyClinicalTrialsFargo@sanfordhealth.org
Principal Investigator: Preston D. Steen
Sanford Roger Maris Cancer Center
Fargo, North Dakota
Contact: Site Public Contact 701-234-6161 OncologyClinicalTrialsFargo@sanfordhealth.org
Principal Investigator: Preston D. Steen
Cleveland Clinic Akron General
Akron, Ohio
Contact: Site Public Contact 866-223-8100 CancerAnswer@ccf.org
Principal Investigator: Esther H. Rehmus
Strecker Cancer Center-Belpre
Belpre, Ohio
Contact: Site Public Contact 800-523-3977 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio
Contact: Site Public Contact 937-528-2900 clinical.trials@daytonncorp.org
Principal Investigator: Howard M. Gross
Miami Valley Hospital South
Centerville, Ohio
Contact: Site Public Contact 937-528-2900 clinical.trials@daytonncorp.org
Principal Investigator: Howard M. Gross
Adena Regional Medical Center
Chillicothe, Ohio
Contact: Site Public Contact 877-779-7585 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
University of Cincinnati/Barrett Cancer Center
Cincinnati, Ohio
Contact: Site Public Contact 513-558-4553 uchealthnews@uc.edu
Principal Investigator: Jordan Kharofa
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio
Contact: Site Public Contact 866-223-8100 TaussigResearch@ccf.org
Principal Investigator: Mark K. Kyei
Ohio State University Comprehensive Cancer Center
Columbus, Ohio
Contact: Site Public Contact 800-293-5066 Jamesline@osumc.edu
Principal Investigator: John L. Hays
Mount Carmel East Hospital
Columbus, Ohio
Contact: Site Public Contact 614-488-2118 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio
Contact: Site Public Contact 614-488-2118 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Riverside Methodist Hospital
Columbus, Ohio
Contact: Site Public Contact 614-566-4475 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Grant Medical Center
Columbus, Ohio
Contact: Site Public Contact 614-566-4475 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
The Mark H Zangmeister Center
Columbus, Ohio
Contact: Site Public Contact 614-488-2118 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Mount Carmel Health Center West
Columbus, Ohio
Contact: Site Public Contact 614-234-5433 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Doctors Hospital
Columbus, Ohio
Contact: Site Public Contact 614-566-3275 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Miami Valley Hospital
Dayton, Ohio
Contact: Site Public Contact 937-528-2900 clinical.trials@daytonncorp.org
Principal Investigator: Howard M. Gross
Delaware Health Center-Grady Cancer Center
Delaware, Ohio
Contact: Site Public Contact 740-615-0227 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Grady Memorial Hospital
Delaware, Ohio
Contact: Site Public Contact 740-615-2403 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Greater Dayton Cancer Center
Kettering, Ohio
Contact: Site Public Contact 937-528-2900 clinical.trials@daytonncorp.org
Principal Investigator: Howard M. Gross
Fairfield Medical Center
Lancaster, Ohio
Contact: Site Public Contact 740-687-8863 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
OhioHealth Mansfield Hospital
Mansfield, Ohio
Contact: Site Public Contact 419-526-8018 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio
Contact: Site Public Contact 866-223-8100 TaussigResearch@ccf.org
Principal Investigator: Mark K. Kyei
Marietta Memorial Hospital
Marietta, Ohio
Contact: Site Public Contact 800-523-3977 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
OhioHealth Marion General Hospital
Marion, Ohio
Contact: Site Public Contact 614-488-2118 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio
Contact: Site Public Contact 866-223-8100 TaussigResearch@ccf.org
Principal Investigator: Mark K. Kyei
Knox Community Hospital
Mount Vernon, Ohio
Contact: Site Public Contact 740-393-9000 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Licking Memorial Hospital
Newark, Ohio
Contact: Site Public Contact 740-348-4000 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Southern Ohio Medical Center
Portsmouth, Ohio
Contact: Site Public Contact 614-488-2118 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
North Coast Cancer Care
Sandusky, Ohio
Contact: Site Public Contact 866-223-8100 TaussigResearch@ccf.org
Principal Investigator: Mark K. Kyei
ProMedica Flower Hospital
Sylvania, Ohio
Contact: Site Public Contact 419-824-1842
Principal Investigator: Feng Jiang
South Pointe Hospital
Warrensville Heights, Ohio
Contact: Site Public Contact 866-223-8100 TaussigResearch@ccf.org
Principal Investigator: Mark K. Kyei
University Pointe
West Chester, Ohio
Contact: Site Public Contact clinicaltrials@ucphysicians.com
Principal Investigator: Jordan Kharofa
Saint Ann's Hospital
Westerville, Ohio
Contact: Site Public Contact 614-234-5433 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio
Contact: Site Public Contact 740-454-5232 sheree@columbusccop.org
Principal Investigator: Timothy D. Moore
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma
Contact: Site Public Contact 877-231-4440
Principal Investigator: Susanna V. Ulahannan
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
Contact: Site Public Contact 405-271-8777 ou-clinical-trials@ouhsc.edu
Principal Investigator: Susanna V. Ulahannan
Cancer Treatment Centers of America
Tulsa, Oklahoma
Contact: Site Public Contact 412-339-5294 Roster@nrgoncology.org
Principal Investigator: Asha Karippot
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma
Contact: Site Public Contact 918-505-3200
Principal Investigator: Susanna V. Ulahannan
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon
Contact: Site Public Contact 503-215-2614 CanRsrchStudies@providence.org
Principal Investigator: Krishna C. Alluri
Providence Newberg Medical Center
Newberg, Oregon
Contact: Site Public Contact 503-215-2614 CanRsrchStudies@providence.org
Principal Investigator: Krishna C. Alluri
Saint Alphonsus Medical Center-Ontario
Ontario, Oregon
Contact: Site Public Contact 734-712-3671 stephanie.couch@stjoeshealth.org
Principal Investigator: John M. Schallenkamp
Providence Portland Medical Center
Portland, Oregon
Contact: Site Public Contact 503-215-2614 CanRsrchStudies@providence.org
Principal Investigator: Krishna C. Alluri
Providence Saint Vincent Medical Center
Portland, Oregon
Contact: Site Public Contact 503-215-2614 CanRsrchStudies@providence.org
Principal Investigator: Krishna C. Alluri
Pennsylvania
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania
Contact: Site Public Contact 734-712-3671 stephanie.couch@stjoeshealth.org
Principal Investigator: Tareq Al Baghdadi
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania
Contact: Site Public Contact 734-712-3671 stephanie.couch@stjoeshealth.org
Principal Investigator: Tareq Al Baghdadi
Saint Vincent Hospital
Erie, Pennsylvania
Contact: Site Public Contact 814-452-5000
Principal Investigator: Amjad Jalil
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania
Contact: Site Public Contact 717-724-6765 klitchfield@PINNACLEHEALTH.org
Principal Investigator: Anuradha Krishnamurthy
Jefferson Hospital
Jefferson Hills, Pennsylvania
Contact: Site Public Contact 412-359-3043 ddefazio@wpahs.org
Principal Investigator: Amjad Jalil
Forbes Hospital
Monroeville, Pennsylvania
Contact: Site Public Contact 412-858-7746
Principal Investigator: Amjad Jalil
Allegheny Valley Hospital
Natrona Heights, Pennsylvania
Contact: Site Public Contact 724-226-7380
Principal Investigator: Amjad Jalil
Allegheny General Hospital
Pittsburgh, Pennsylvania
Contact: Site Public Contact 877-284-2000
Principal Investigator: Amjad Jalil
West Penn Hospital
Pittsburgh, Pennsylvania
Contact: Site Public Contact 412-578-5000
Principal Investigator: Amjad Jalil
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania
Contact: Site Public Contact 412-647-8073
Principal Investigator: Anuradha Krishnamurthy
Reading Hospital
West Reading, Pennsylvania
Contact: Site Public Contact 610-988-9323
Principal Investigator: Terrence P. Cescon
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania
Contact: Site Public Contact 412-359-3043 ddefazio@wpahs.org
Principal Investigator: Amjad Jalil
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Prisma Health Cancer Institute - Easley
Easley, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Saint Francis Hospital
Greenville, South Carolina
Contact: Site Public Contact 864-603-6213 melissa_beckman@bshsi.org
Principal Investigator: Robert D. Siegel
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Prisma Health Cancer Institute - Faris
Greenville, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Saint Francis Cancer Center
Greenville, South Carolina
Contact: Site Public Contact 864-603-6213 melissa_beckman@bshsi.org
Principal Investigator: Robert D. Siegel
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Prisma Health Cancer Institute - Greer
Greer, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina
Contact: Site Public Contact 864-522-2066 kim.williams3@prismahealth.org
Principal Investigator: Jeffrey K. Giguere
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota
Contact: Site Public Contact 605-312-3320 OncologyClinicTrialsSF@sanfordhealth.org
Principal Investigator: Preston D. Steen
Avera Cancer Institute
Sioux Falls, South Dakota
Contact: Site Public Contact 605-322-3095 OncRegulatory@avera.org
Principal Investigator: Benjamin M. Solomon
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota
Contact: Site Public Contact 605-312-3320 OncologyClinicalTrialsSF@SanfordHealth.org
Principal Investigator: Preston D. Steen
Wellmont Bristol Regional Medical Center
Bristol, Tennessee
Contact: Site Public Contact 423-578-8538 justin.reynolds@wellmont.org
Principal Investigator: Asheesh Shipstone
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee
Contact: Site Public Contact 901-226-1366 BCCclintrials@bmhcc.org
Principal Investigator: Shailesh R. Satpute
Regional Cancer Center at Indian Path Community Hospital
Kingsport, Tennessee
Contact: Site Public Contact 423-578-8538 Justin.reynolds@balladhealth.org
Principal Investigator: Asheesh Shipstone
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee
Contact: Site Public Contact 423-578-8538 justin.reynolds@wellmont.org
Principal Investigator: Asheesh Shipstone
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee
Contact: Site Public Contact 901-226-1366 BCCclintrials@bmhcc.org
Principal Investigator: Shailesh R. Satpute
The Don and Sybil Harrington Cancer Center
Amarillo, Texas
Contact: Site Public Contact 806-212-1985 Gina.Cravey@bsahs.org
Principal Investigator: Anita Ravipati
Parkland Memorial Hospital
Dallas, Texas
Contact: Site Public Contact 214-590-5582 canceranswerline@UTSouthwestern.edu
Principal Investigator: Syed M. Kazmi
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas
Contact: Site Public Contact 214-648-7097 canceranswerline@UTSouthwestern.edu
Principal Investigator: Syed M. Kazmi
Houston Methodist Hospital
Houston, Texas
Contact: Site Public Contact 713-790-2700
Principal Investigator: Maen Abdelrahim
M D Anderson Cancer Center
Houston, Texas
Contact: Site Public Contact 877-632-6789 askmdanderson@mdanderson.org
Principal Investigator: Michael J. Overman
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah
Contact: Site Public Contact 888-424-2100 cancerinfo@hci.utah.edu
Principal Investigator: Heloisa P. Soares
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont
Contact: Site Public Contact 802-473-4100
Principal Investigator: Kathryn C. Hourdequin
Wellmont Medical Associates-Bristol
Bristol, Virginia
Contact: Site Public Contact 423-578-8538 justin.reynolds@wellmont.org
Principal Investigator: Asheesh Shipstone
Kaiser Permanente-Burke Medical Center
Burke, Virginia
Contact: Site Public Contact Diane.Fisher@nsmtp.kp.org
Principal Investigator: Leon C. Hwang
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia
Contact: Site Public Contact 540-332-5960
Principal Investigator: Kelvin B. Raybon
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg, Virginia
Contact: Site Public Contact 434-200-5925 Kevin.Patel@centrahealth.com
Principal Investigator: Khalid Matin
Southwest VA Regional Cancer Center
Norton, Virginia
Contact: Site Public Contact 423-578-8538 justin.reynolds@wellmont.org
Principal Investigator: Asheesh Shipstone
VCU Massey Cancer Center at Stony Point
Richmond, Virginia
Contact: Site Public Contact 804-628-1939 mwellons@vcu.edu
Principal Investigator: Khalid Matin
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia
Contact: Site Public Contact 804-628-1914 klcampbell@vcu.edu
Principal Investigator: Khalid Matin
VCU Community Memorial Health Center
South Hill, Virginia
Contact: Site Public Contact 434-774-2442 sherman.baker@vcuhealth.org
Principal Investigator: Khalid Matin
Swedish Cancer Institute-Issaquah
Issaquah, Washington
Contact: Site Public Contact 206-215-3086 PCRC-NCORP@Swedish.org
Principal Investigator: Krishna C. Alluri
Jefferson Healthcare
Port Townsend, Washington
Contact: Site Public Contact 360-344-3091
Principal Investigator: Nicholas DiBella
Swedish Medical Center-First Hill
Seattle, Washington
Contact: Site Public Contact 206-215-3086 PCRC-NCORP@Swedish.org
Principal Investigator: Krishna C. Alluri
West Virginia University Charleston Division
Charleston, West Virginia
Contact: Site Public Contact 304-388-9944
Principal Investigator: Steven J. Jubelirer
Langlade Hospital and Cancer Center
Antigo, Wisconsin
Contact: Site Public Contact 715-623-9869 Juli.Alford@aspirus.org
Principal Investigator: Harish G. Ahuja
ThedaCare Regional Cancer Center
Appleton, Wisconsin
Contact: Site Public Contact 920-364-3605 ResearchDept@thedacare.org
Principal Investigator: Xin Yao
Ascension Saint Elizabeth Hospital
Appleton, Wisconsin
Contact: Site Public Contact 414-635-6420 AWRI.inquiry@ascension.org
Principal Investigator: Kamal Kant Singh Abbi
Duluth Clinic Ashland
Ashland, Wisconsin
Contact: Site Public Contact 218-786-3308 CancerTrials@EssentiaHealth.org
Principal Investigator: Bret E. Friday
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield, Wisconsin
Contact: Site Public Contact 414-635-6420 AWRI.Inquiry@Ascension.org
Principal Investigator: Francis J. Cuevas
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin
Contact: Site Public Contact 800-782-8581 oncology.clinical.trials@marshfieldresearch.org
Principal Investigator: Isaac K. Yeboah
Ascension Saint Francis - Reiman Cancer Center
Franklin, Wisconsin
Contact: Site Public Contact 414-635-6420 AWRI.Inquiry@Ascension.org
Principal Investigator: Francis J. Cuevas
Bellin Memorial Hospital
Green Bay, Wisconsin
Contact: Site Public Contact 920-435-8326
Principal Investigator: Hassan I. Tahsildar
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin
Contact: Site Public Contact 608-756-6871 oncologyclinicaltrials@mhemail.org
Principal Investigator: Emily G. Robinson
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin
Contact: Site Public Contact 920-699-3500 lynda.persico@uwmf.wisc.edu
Principal Investigator: Daniel L. Mulkerin
Gundersen Lutheran Medical Center
La Crosse, Wisconsin
Contact: Site Public Contact 608-775-2385 cancerctr@gundersenhealth.org
Principal Investigator: Kurt Oettel
University of Wisconsin Hospital and Clinics
Madison, Wisconsin
Contact: Site Public Contact 800-622-8922
Principal Investigator: Daniel L. Mulkerin
Aspirus Medford Hospital
Medford, Wisconsin
Contact: Site Public Contact 715-847-2353 Beth.Knetter@aspirus.org
Principal Investigator: Harish G. Ahuja
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin
Contact: Site Public Contact 800-782-8581 oncology.clinical.trials@marshfieldresearch.org
Principal Investigator: Isaac K. Yeboah
ProHealth D N Greenwald Center
Mukwonago, Wisconsin
Contact: Site Public Contact research.institute@phci.org
Principal Investigator: Timothy R. Wassenaar
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin
Contact: Site Public Contact 262-928-7878
Principal Investigator: Timothy R. Wassenaar
Ascension Mercy Hospital
Oshkosh, Wisconsin
Contact: Site Public Contact 920-831-8900 Dale.grimmer@ascension.org
Principal Investigator: Kamal Kant Singh Abbi
Ascension All Saints Hospital
Racine, Wisconsin
Contact: Site Public Contact 414-635-6420 AWRI.Inquiry@Ascension.org
Principal Investigator: Francis J. Cuevas
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin
Contact: Site Public Contact 800-782-8581 oncology.clinical.trials@marshfieldresearch.org
Principal Investigator: Isaac K. Yeboah
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin
Contact: Site Public Contact 800-782-8581 oncology.clinical.trials@marshfieldresearch.org
Principal Investigator: Isaac K. Yeboah
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin
Contact: Site Public Contact 262-928-7632
Principal Investigator: Timothy R. Wassenaar
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin
Contact: Site Public Contact 262-928-5539 Chanda.miller@phci.org
Principal Investigator: Timothy R. Wassenaar
Aspirus Regional Cancer Center
Wausau, Wisconsin
Contact: Site Public Contact 877-405-6866
Principal Investigator: Harish G. Ahuja
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa, Wisconsin
Contact: Site Public Contact 414-635-6420 AWRI.Inquiry@Ascension.org
Principal Investigator: Francis J. Cuevas
Marshfield Medical Center - Weston
Weston, Wisconsin
Contact: Site Public Contact 800-782-8581 oncology.clinical.trials@marshfieldresearch.org
Principal Investigator: Isaac K. Yeboah
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin
Contact: Site Public Contact 715-422-7718
Principal Investigator: Harish G. Ahuja
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming
Contact: Site Public Contact 303-777-2663 ccrp@co-cancerresearch.org
Principal Investigator: Nicholas DiBella
Study Contact Information:
For additional information, please contact:
Principal Investigator: Caio M
This Study is Open To:
Men or women age 18 years or older can participate if they:
- Have metastatic colon or rectal cancer without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer
- Tumor determined to be mismatch-repair deficient (dMMR); patients with MSI-H diagnosis are also eligible
- Have no immediate need for surgical intervention
This Study is Not Open To:
Patients will be excluded if they:
- Have central nervous system (CNS) metastases (Contact the study team to review a list of exceptions)
- Have uncontrolled high blood pressure
- Have a severe cardiac condition
- Have a serious or non-healing wound, skin ulcer, or bone fracture
- Have a history of transient ischemic attack (TIA), cerebrovascular accident (CVA), gastrointestinal (GI) perforation or blood clot within 6 months prior to study enrollment
- Have had prior treatment with anti-PD-1 or anti-PD-L1 therapy (also known as immune check point inhibitors)
- Have clinically significant liver disease
- Have a history or risk of autoimmune disease (Contact the study team to review a list of exceptions)
- Have a history of lung tissue inflammation or lung disease
- Have known active tuberculosis (TB)
- Women who are pregnant
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.