Clinicaltrials.gov identifier:
NCT05287451 (https://clinicaltrials.gov/show/NCT05287451)
Prevention
Prevention study for women at high risk for ovarian cancer
Study Contact Information:
Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email: rnitecki@mdanderson.org
This study is looking at whether removal of the fallopian tubes (salpingectomy) followed by removal of the ovaries (oophorectomy) at a later date closer to the time of natural menopause may reduce the risk of ovarian cancer nearly as much as removing both the ovaries and fallopian tubes at the same time (salpingo-oophorectomy) among women with an inherited BRCA1, BRCA2, BRIP1, RAD51C or RAD51D mutation. Removing the fallopian tubes only first and the ovaries at a later time closer to natural menopause may lessen menopausal symptoms while still lowering the risk for ovarian cancer.
Participants in this study will enroll in one of two groups. Participants will choose which group they enroll in based on their surgical preference.
Massachusetts
Boston
Harvard Cancer Center
Contact: Colleen Feltmate, MD by phone 617-732-8843 or email cfeltmate@bwh.harvard.edu
Missouri
St. Louis
Washington Univeristy School of Medicine
Contact: Andrea Hagemann, MD by phone 314-362-3181 or by email hagemann@wustl.edu
Texas
Houston
M D Anderson Cancer Center
Contact: Roni Wilke, MD by phone (713) 822-4502 or by email: rnitecki@mdanderson.org
Washington
Seattle
University of Washington Cancer Center
Contact: Barb Norquist, MD by email: bnorquis@uw.edu or contact the study coordinator at: 206-616-3913
Women are eligible if they:
Are premenopausal with a documented inherited mutation in one of the genes listed below. Eligible age depends on gene mutation.
Have at least one fallopian tube
Do not wish to be pregnant in the future
Women cannot participate if they:
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.