Pancreatic Cancer Screening Study (CAPS5)

About the Study

CAP5 is a study looking at screening for early cancer in people with an elevated lifetime risk of developing pancreatic cancer who are undergoing screening with endospic ultrasound (EUS,) MRI or CT scan. The goal is to study biomarkers derived from images and tissue samples (ex. blood, pancreas fluid, duodenal fluid) for the early detection of pancreatic cancer and precancerous lesions. 

What the Study Involves

Study participation involves:

• answering online questionnaires.
• donating 4 tubes of blood- for research only.
• (at some sites) collecting free standing fluid in the duodenal area where the pancreas drains fluid, aspirated by scope during EUS procedures- for research only.
• (at some sites and optional) collect pancreas juice via the endoscope.  The pancreas is stimulated by a dose of Secretin, a synthetic pancreas hormone, injected I.V during the EUS procedure-for research only.
• data from the participants medical record related to their pancreas screening and care.
• optional: potential early detection blood test, pairing annual CA19-9 with the participants FUT2/FUT3 gene test to individualize the CA19-9 result. Results will be shared with the participant.

NOTE: The CAPS 5 study does not provide payment for participation and all screening tests will be submitted to the patients insurance for payment.  These screening test/procedures are standard care for pancreas cancer screening for high risk individuals. For research participants, data will be collected from all screening tests/ reports for various CAPS 5 projects, but their pancreas screening will not be altered by their study participation. 

Study Locations

Connecticut

• New Haven
  Contact: Scott Merenda by phone: 203-785-7019 or email: scott.merenda@yale.edu  
  Lead researcher: James Farrell, MD         

Maryland

• Baltimore
  Johns Hopkins Hospital
  Contact: Hilary Cosby by phone 410-502-2893 or email: hcosby1@jhmi.edu   
  Lead researchers: Michael Goggins, MD and Marcia I Canto, MD         

Massachusetts

• Boston
  Dana Farber Cancer Center 
  Contact: Chinedu Ukaegbu by email: chinedu_ukaegbu@dfci.harvard.edu   
  Lead researcher: Sapna Syngal, MD         

Michigan

• Ann Arbor, Michigan
  University of Michigan
  Contact: Sarah Volk by phone: 734-936-5704 or email: stomanic@umich.edu 
  Researcher: Elena Stoffel, MD         

New York

• New York City
  Columbia University Medical Center
  Contact: Katharine Godfrey by email kb3217@cumc.columbia.edu 
  Researcher: Fay Kastrinos, MD         

Ohio

• Cleveland
  Case Comprehensive Cancer Center
  Contact: Barbara Heaton  by phone: 216-844-7314 or by email:barbara.Heaton@UHhospitals.org
  Researcher: Amitabh Chak, MD         

Pennsylvania

• Philadelphia
  University of Pennsylvania
  Contact: Maureen DeMarshall by phone: 215-349-8546 or email demarshm@mail.med.upenn.edu   
  Contact: Daniel Clay, email Daniel.Clay@Pennmedicine.upenn.edu    
  Researcher: Bryson Katona, MD         
• Pittsburgh
  University of Pittsburgh
  Contact: Christine Decapite by email: decapitec@upmc.edu    
  Researcher: Randall Brand, MD        

This study is open to people at high risk for pancreatic cancer due to any of the following:

• Inherited mutation in the following genes: ATM, BRCA1, BRCA2, FAMMM, PALB2, Lynch syndrome (EPCAM, MLH1, MSH2, MSH6, PMS2), hereditary pancreatitis (PRSS1/2, or CTRC), STK11 (Peutz-Jeghers)
• With two or more close relatives, on one side of their family tree, diagnosed with pancreas cancer 
• Endoscopic evaluation of pancreas scheduled

*contact your doctors or the study coordinators for a complete list of inclusion criteria.

This study is not open to people who:

• are unable to have an endoscopy
• are pregnant