Lynch Syndrome Vaccine Study
https://www.facingourrisk.org/research-clinical-trials/study/273/testing-a-combination-of-vaccines-for-cancer-prevention-in-lynch-syndrome
Clinicaltrials.gov identifier:
NCT05419011 (https://clinicaltrials.gov/show/NCT05419011)
Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome
Study Contact Information:
For more information, please contact ncpc@northwestern.edu
About the Study
Lynch Syndrome (LS) increases the risk of colon cancer and other cancers, including cancer of the uterus, ovaries, small bowel, stomach, pancreas, urinary tract, skin, and brain.
This study is being done to assess the safety and effectiveness of a series of vaccines (Tri-Ad5), together with another drug (N-803) that magnifies the body’s response to vaccines, to see if there is an effect on the risk of developing colon and other cancers in LS patients.
For more Information, visit https://bit.ly/ihavelynch
What the Study Involves
If you consent and are eligible to join this trial, you will attend a total of 8 study appointments. During these visits you will receive a series of injections (3-4 injections four times over a one-year period) and undergo yearly colonoscopies as part of routine care. You can also expect physical exams, blood draws, review of your medical history, and completion of questionnaires and a vaccine report card to report any injection side effects.
Study Locations
Arizona
- Tucson, AZ
University of Arizona Cancer Center - Prevention Research Clinic
Lead Research, Aaron Scot:
Contact: Aaron J. Scott 520-626-6453 ajscott@arizona.edu
Illinois
- Chicago, IL
Northwestern University
Lead Researcher: Mohammad A. Abbass
Contact: Mohammad A. Abbass 312-694-4789 Mohammad.Abbass@nm.org
Kansas
- Kansas City, KS
University of Kansas Medical Center
Lead Researcher: Ajay Bansal, MD
Contact: 913-588-6003 abansal@kumc.edu
Massachusetts
- Boston, MA
Dana-Farber Cancer Institute
Lead Researcher: Ramona M. Lim, MD
Contact: 617-582-7777 ColonScreening@DFCI.harvard.edu
Michigan
- Ann Arbor, MI
University of Michigan Comprehensive Cancer Center
Lead Researcher: Elena Stoffel, MD
Contact: 734-936-0781 estoffel@med.umich.edu
Texas
- Houston, TX
University of Texas MD Anderson Cancer Center, Houston, TX
Lead Researcher: Eduardo Vilar-Sanchez, MD, PhD
Contact: 713-563-4743 EVilar@mdanderson.org
This Study is Open To:
People 18 years or older who:
- Have been diagnosed with Lynch syndrome and have had abnormal growths in their colon or rectum.
- Have not had any cancer treatment in the past 6 months.
- Are not pregnant or planning to get pregnant.
This Study is Not Open To:
People who do not meet the eligibility criteria defined above and those who:
- Have experienced severe side effects or allergic reations to previous vaccines.
- Have a blood clotting disorder.
- Have had organ transplants.
- Are pregnant or breastfeeding.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.