The LiFT UP Li-Fraumeni & TP53: Understanding & Progress Study
https://www.facingourrisk.org/research-clinical-trials/study/307/the-lift-up-study
Clinicaltrials.gov identifier:
NCT04541654 (https://clinicaltrials.gov/show/NCT04541654)
Surveys, Registries, Interviews
Study looking at cancer risk for people with Li-Fraumeni syndrome
Study Contact Information:
Please contact the study team at (617) 632-4795 or liftupstudy@DCFI.HARVARD.edu or liftup@coh.org
About the Study
The LiFT UP Study is a research project for individuals and families from around the world. The goal is to learn more about adults and children who have a change in the TP53 gene in their blood to better predict their specific cancer risks. This may be Li-Fraumeni syndrome (LFS) or something else, which we will examine in the LiFT UP Study. This is a collaborative study, so you may join even if you already participate in other LFS studies!
Help us to learn more about cancer risks for families with Li-Fraumeni syndrome and other TP53 gene changes.
What the Study Involves
Participating in our study means you’ll be asked to consider the following:
- Speaking with a member of the study team, who will reach out to you using the information you provide on the eligibility form.
- Signing a consent form to participate.
- Filling out a questionnaire about your personal and family history, then short follow-up questionnaires each year.
- Sharing your medical records related to your TP53 genetic test and any cancers you may have had. All records will be kept confidential.
- Providing a blood and saliva sample at no cost to you (and possibly, a blood draw and/or saliva sample may be done once a year).
- Providing some eyebrow hairs.
- Answering short questionnaires periodically.
- We may ask you to consider inviting family members to enroll.
Study Sites
Massachusetts
Boston
Boston Children's Hopsital
Contact: Junne Kamihara, MD at (888) 733-4662 or jkamihara@partners.org
Lead Researcher: Junne Kamihara, MD
Bringham and Women's Hospital
Contact: Judy Garber, MD, MPH at (617) 632-2282 or jegarber@partners.org
Lead Researcher: Judy Garbar, MD, MPH
Dana-Farber Cancer Institute
Contact: Judy Garber, MD, MPH at (617) 763-8821 or judy_garber@dfci.harvard.edu
This Study is Open To:
You may be eligible to join the study if you have any of the following:
- A TP53 genetic mutation found on genetic testing
- A blood relative who has a TP53 genetic mutation
- A TP53 finding on genetic testing and a diagnosis of "CHIP" or "ACE"
This Study is Not Open To:
You are not eligible for the study if you:
- Do not have a TP53 genetic mutation found on genetic testing, or
- Do not have a blood relative who has a TP53 genetic mutation, or
- Do not have a TP53 finding on genetic testing and a diagnosis of "CHIP" or "ACE"
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.