FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
XRAY is a reliable source of hereditary cancer research-related news and information.
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Ovarian Cancer
Update : PARP inhibitors withdrawn as third-line or later treatment for recurrent ovarian cancer
Most relevant for: people with recurrent ovarian cancer who have received 3 or more prior lines of treatment and who have an inherited or tumor mutation in BRCA1 or BRCA2 or whose tumor is HRD positive
Survival data from a clinical trial signaled that PARP inhibitors may not work as well as chemotherapy for patients with recurrent ovarian cancer who have received three or more lines of treatment. As a result, FDA approvals have been withdrawn for PARP inhibitors in this setting. This does not affect PARP inhibitor approvals for use as maintenance therapy for ovarian cancer. (Posted 10/4/22)
Este artículo está disponible en español.
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Relevance: Medium-High
Strength of Science: High
Research Timeline: Post Approval
Study : Physical activity may decrease fatigue associated with cancer treatment
Relevance: Medium-High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: Cancer patients who are experiencing fatigue related to cancer or its treatment.
Many cancer survivors experience fatigue during and after they complete treatment. This study looked at the effect of home-based physical activity on fatigue in cancer survivors. It also looked at whether frequent counseling encouraged people to start and continue their exercise routines. (Posted 8/1/22). Este artículo está disponible en español.
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Relevance: High
Quality of Writing: Medium-High
Article : How your ovarian cancer diagnosis can help your relatives
Relevance: High
Quality of Writing: Medium-High
Most relevant for: People diagnosed with ovarian cancer
This media article provides tips from experts and the CDC for talking to family members after a diagnosis of ovarian cancer. It highlights which family members may be at risk of developing ovarian cancer or passing on genes that increase risk. The article provides links to resources, talking points, alternative methods of communication and potential reactions. (Posted 7/28/22)
Este artículo está disponible en español.
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Relevance: Medium-High
Strength of Science: High
Research Timeline: Human Research
Study : Risk-reducing ovarian cancer surgery and quality of life
Relevance: Medium-High
Strength of Science: High
Research Timeline: Human Research
Most relevant for: People with an inherited BRCA mutation
People with an inherited BRCA gene mutation are recommended to have surgery to remove their ovaries before the age of natural menopause to reduce their risk of ovarian cancer. This surgery can cause short-term and long-term effects. This study assesses the quality of life among people who have their fallopian tubes surgically removed and later have their ovaries removed compared to people who have their ovaries and fallopian tubes removed at the same time. (Posted 7/26/22). Este artículo está disponible en español.
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Relevance: High
Strength of Science: Medium-High
Research Timeline: Post Approval
Study : The hidden financial burden of treating cancer care symptoms
Relevance: High
Strength of Science: Medium-High
Research Timeline: Post Approval
Most relevant for: People who are experiencing side effects due to cancer treatment or cancer.
Drugs commonly used to treat symptoms of cancer and cancer treatment side effects can cost thousands of dollars out of pocket for patients, depending on what drugs are used. (Posted 6/29/2022). Este artículo está disponible en español.
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Relevance: Medium
Strength of Science: Medium-High
Research Timeline: Post Approval
Study : Increasing melatonin use raises concerns
Relevance: Medium
Strength of Science: Medium-High
Research Timeline: Post Approval
Most relevant for: people who take or consider taking melatonin to help with sleep.
Adult use of melatonin as a sleep aid has increased even though its benefits and risks are not well understood. This study looked at trends in melatonin use over the last 19 years. (Posted 4/14/2022)
Este artículo está disponible en español.
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Relevance: High
Quality of Writing: Medium-High
Research Timeline: Post Approval
Article : Chris Evert's ovarian cancer diagnosis highlights the importance of genetic counseling and testing
Relevance: High
Quality of Writing: Medium-High
Research Timeline: Post Approval
Most relevant for: People with genetic test result called a VUS
Tennis star Chris Evert shared her story about a change in her sister's genetic test results that led Ms. Evert to have genetic testing and her decision to have her ovaries removed to lower her cancer risk. Ovarian cancer was found at the time of Ms. Evert’s surgery, but fortunately, it was caught early. Her story highlights the importance of genetic counseling, testing and post-testing follow-up with experts. (Posted 2/8/22). Este artículo está disponible en español.
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Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Human Research
Study : Cannabis use among breast cancer patients
Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Human Research
Most relevant for: People interested in using cannabis to relieve treatment side effects.
This study looked at patterns of cannabis use among breast cancer patients who are members of online health communities. Almost half of the study participants reported using cannabis to help manage treatment symptoms and side effects. The study also looked at reasons why patients used cannabis, where they obtained it and whether they perceived cannabis to be safe. While this study only looked at cannabis use among breast cancer patients it is likely results would be similar among patients diagnosed with other types of cancers. (posted 1/25/22)
Este artículo está disponible en español.
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Relevance: High
Strength of Science: Medium-High
Research Timeline: Post Approval
Study : Genetic testing for inherited mutations may be helpful for all people with advanced or metastatic cancer
Relevance: High
Strength of Science: Medium-High
Research Timeline: Post Approval
Most relevant for: people with metastatic or recurrent cancer
In a study of nearly 12,000 cancer patients with a variety of cancers, eight percent of participants with metastatic cancer had an inherited mutation in a cancer gene that qualified them for a targeted treatment approved by the FDA or for participation in a clinical trial. The majority of people with metastatic cancer were unaware that they had an inherited mutation, and had not receive gene-directed treatment to which their tumor may have responded. The study authors suggest that genetic testing for inherited mutations may be warranted for all patients with advanced or metastatic cancer. (posted 9/30/21)
Este artículo está disponible en español.
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Update : Blood tests called liquid biopsies for cancer screening, monitoring and treatment
Most relevant for: People considering a liquid biopsy to screen for cancer
Could a simple blood test change cancer detection, treatment and monitoring? Several companies are offering a type of blood test known as a liquid biopsy to detect multiple cancers at their earliest stages, monitor response to treatment and help choose the best treatment. Although progress has been made using liquid biopsies to treat cancer, these tests have not yet been shown to detect cancer early enough to save lives. (posted 9/29/21)
Este artículo está disponible en español.
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