Care for Transgender and Nonbinary People
Care for Transgender and Nonbinary People
Transgender, nonbinary and other gender-diverse individuals with inherited mutations may have different risks and risk-management options than people with the same mutation. Although there has been little research on in transgender people, experts have begun to develop guidelines for transgender people with risk based on what is known.
risk in transgender and nonbinary people
Depending on the type of cancer, several factors play a role in cancer risk, including:
- sex assigned at birth
- gender-affirming surgery
- gender-affirming hormone therapy
- pregnancy
The cancers most likely to be effected by these factors include breast cancer and cancers related to the reproductive system. The table below lists these cancers and their related genes.
Cancer Type |
Genes |
Breast |
ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53 |
Endometrial |
BRCA1*, BRCA2*, EPCAM, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, PTEN
|
Ovarian |
BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2*, RAD51C, RAD51D |
Prostate |
ATM, BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6*, PMS2* |
*More research is needed to confirm a link between this gene and this type of cancer. |
|
It's important to assemble a team of healthcare professionals who are knowledgeable about medical considerations related to risk in transgender people. These experts may not all work at the same facility. Try to find providers who are willing to work with one another to provide you with the best care possible.
See below for more information on medical considerations for transmasculine, transfeminine, nonbinary and other gender-diverse people.
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More Information on for Transgender People
Transmasculine People
Read more about hereditary cancer risk and medical options for trans men, transmasculine, nonbinary and other gender-diverse people assigned female at birth.
Transfeminine People
Read more about hereditary cancer risk and medical options for trans women, transfeminine, nonbinary and other gender-diverse people assigned male at birth.