FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
XRAY is a reliable source of hereditary cancer research-related news and information.
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Relevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsStudy : Early research on a drug to prevent breast cancer
Relevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsMost relevant for: Women with a BRCA1 mutation
Many researchers are interested in non-surgical options to reduce the higher-than-average risk of developing breast cancer in BRCA mutation carriers. This research study identified a type of drug, called a “RANK ligand inhibitor,” that may prevent breast cancer. Among mice that were genetically engineered to have no BRCA1 genes, those that were given the drug developed tumors less frequently than those that did not. While this is an exciting early study for BRCA mutation carriers, more work and human clinical trials need to be done before this can be used as a prevention therapy in humans. (7/12/16)
Update added 11/24/19: The RANK ligand inhibitor, denosumab is currently being studied as a possible breast and ovarian cancer preventive agent in human clinical trials.
Read MoreRelevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsStudy : Breast cancer risk model updated for average risk women with genetic, lifestyle and environmental information
Relevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsMost relevant for: Women at average risk for breast cancer
A number of factors are known to increase breast cancer risk, but some of these factors have not been included in models to predict breast cancer risk. This study looks at an updated model that includes some of these factors, such as genetics, smoking, and drinking. The goal of the model is to give women a more individualized breast cancer risk assessment. (6/29/16)
Read MoreStudy : Does light alcohol consumption affect your breast cancer risk?
Most relevant for: Women who drink alcohol and are concerned about their breast cancer risk.
Alcohol is known to increase breast cancer risk, but does that include light consumption? This study indicates that some breast cancer occurrences and mortality is due to light alcohol consumption. (06/21/16)
Read MoreRelevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Human Research
View Related Clinical TrialsStudy : Dense breast notifications are informative but hard to read and understand
Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Human Research
View Related Clinical TrialsMost relevant for: Women with dense breast tissue on mammograms
Some states offer women dense breast notifications that are meant to explain that dense breasts are risk factors for breast cancer and can hide cancer on mammograms, and to identify appropriate supplemental screening options. But recent research found that this information is often not easy to read or understand, which questions the usefulness of the documents. (6/7/16)
Read MoreStudy : Can long periods of fasting protect against breast cancer recurrence?
Most relevant for: Breast cancer survivors
Previous research in mice suggested that long periods of fasting provide protection against factors that are associated with a poor cancer outcome. A new study associates prolonged fasting (13 hours or more) at night with a lower risk of breast cancer recurrence, but no association between fasting time at night and mortality. While these findings are interesting, more research needs to be done to confirm them. In the meantime, breast cancer survivors should discuss any concerns about nutrition with their health care providers. 05/30/16
Read MoreRelevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsStudy : Do BRCA mutations affect fertility?
Relevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsMost relevant for: Women with a BRCA mutation who want to become pregnant
Age affects fertility. As women age, their ovaries release eggs that are not as healthy as those released in younger women. Fewer eggs are released each menstrual cycle as women age, making it harder for older women to become pregnant. Are women with BRCA mutations less fertile? Previous research suggested that BRCA mutations might affect women's fertility as she ages. A recent study found that BRCA1 mutation carriers may have slightly lower fertility than women without the same mutation, but more research is needed before this finding is useful for medical decision-making. (5/24/16)
Read MoreStudy : Financial burden affects quality of life of cancer survivors
Most relevant for: People diagnosed with cancer
Cancer-related financial burden can keep survivors from getting the care that they need, yet how this burden affects mental and physical health is still unknown. A study found that almost one-third of cancer survivors report having financial burden; those most likely to be affected were under age 65, female, members of racial or ethnic minority groups, and people who lack access to adequate insurance. (5/17/16)
Read MoreRelevance: Medium
Strength of Science: Medium
Study : More patients with invasive breast cancer opting for double mastectomies
Relevance: Medium
Strength of Science: Medium
Most relevant for: Women diagnosed with breast cancer who are recommended to undergo a single mastectomy
There are a number of surgical options for treating invasive breast cancer. These include lumpectomy with radiation, a single mastectomy to remove only the breast with cancer, or a double mastectomy, which removes both breasts. A new study finds that more women are choosing double mastectomy, even though it does not increase overall survival for these patients. (5/3/2016)
Read MoreRelevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
Study : Cellular diversity in tumors may predict survival for some types of breast cancer
Relevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
Most relevant for: People diagnosed with breast cancer that is "high-grade" or aggressive
Some tumors are made up of many different types of cells, while others contain generally the same cell type. This study found that among people with high-grade breast cancer, those who have tumors made up of many different cell types have a lower 10-year survival rate than people with tumors containing only a single type of cells. This research is an early step towards developing a new test that can help physicians identify cancers that need more aggressive treatment, but more research is needed before it is ready for clinical use. (4/26/16)
Read MoreRelevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsStudy : Is breast cancer risk increased in women who test negative for the BRCA mutation in their family?
Relevance: Medium
Strength of Science: Medium
Research Timeline: Human Research
View Related Clinical TrialsMost relevant for: Women from a family with a known BRCA mutation who tested negative for the mutation in the family
Some women who do not carry a BRCA mutation, but come from a BRCA-positive family, still develop breast cancer. This research examines whether these women are at higher risk for breast cancer, or whether their risk is similar to women in the general population. (4/19/16)
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