FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
XRAY is a reliable source of hereditary cancer research-related news and information.
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Categories Cancer Risk
Article : Breast cancer risk for transgender men with inherited mutations
Most relevant for: Transgender men with an inherited mutation
There is little information related to the risks and treatment options for transgender men and nonbinary people who are at high-risk for breast cancer due to an inherited BRCA1 or BRCA2 mutation. We review an expert viewpoint on the implications of a BRCA mutation for transgender men undergoing breast removal as part of their gender-affirming care plan. (posted 5/19/22)
Este artículo está disponible en español.
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Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Post Approval
Study : New tool to predict breast cancer risk for Black women
Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Post Approval
Most relevant for: Black women in the U.S.
An important part of making decisions about breast cancer screening and prevention is knowing your breast cancer risk. Specific tools are used to identify people who would benefit from early and/or additional screening and chemoprevention or those who would most benefit from genetic counseling and testing. Because these tools were developed using data mostly from white women, they are unable to predict cancer risk as well for Black women. To begin to address these gaps, researchers developed a new tool specifically designed to predict breast cancer risk for Black women. This tool has been shown to work well, especially for younger Black women. (posted 3/22/2022) Este artículo está disponible en español.
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Relevance: High
Strength of Science: Medium-High
Research Timeline: Post Approval
Study : The chance of a second breast cancer is higher among some Hawai'ian women
Relevance: High
Strength of Science: Medium-High
Research Timeline: Post Approval
Most relevant for: women of Hawai’ian, Filipino or Asian American ancestry.
Women diagnosed with ductal carcinoma in situ (DCIS), an early form of breast cancer, are more likely to have a second breast cancer diagnosis if they are of Native Hawai'ian, Filipino or Japanese ancestry than women of other racial or ethnic groups. (posted 3/15/22)
Este artículo está disponible en español.
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Relevance: High
Quality of Writing: Medium-High
Research Timeline: Post Approval
Article : Chris Evert's ovarian cancer diagnosis highlights the importance of genetic counseling and testing
Relevance: High
Quality of Writing: Medium-High
Research Timeline: Post Approval
Most relevant for: People with genetic test result called a VUS
Tennis star Chris Evert shared her story about a change in her sister's genetic test results that led Ms. Evert to have genetic testing and her decision to have her ovaries removed to lower her cancer risk. Ovarian cancer was found at the time of Ms. Evert’s surgery, but fortunately, it was caught early. Her story highlights the importance of genetic counseling, testing and post-testing follow-up with experts. (Posted 2/8/22). Este artículo está disponible en español.
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Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Study : Mutations in BRCA1 or BRCA2 may increase risk for endometrial cancer
Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: People with BRCA1 or BRCA2 mutations
A Dutch study added further evidence that women with a BRCA1 mutation may have an elevated risk for endometrial cancer. The study found that the endometrial cancer in women with either a BRCA1 or BRCA2 mutation was more likely to be an aggressive form of cancer associated with a poor outcomes. (posted 11/30/21)
Este artículo está disponible en español.
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Relevance: Medium
Strength of Science: Medium-High
Research Timeline: Post Approval
Study : Do sugared beverages increase the risk of early-onset colorectal cancer?
Relevance: Medium
Strength of Science: Medium-High
Research Timeline: Post Approval
Most relevant for: Healthy people with an average colorectal cancer risk
A study of female nurses in the U.S. suggests that a high intake of sugar-sweetened beverages may increase the risk of colorectal cancer before age 50. However, researchers saw few early-onset colorectal cancer cases which limited the findings. (posted 9/21/21)
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Article : Transgender peoples' perspectives of being diagnosed with gender-associated cancer
Most relevant for: transgender people
An ABC News article provides viewpoints and data that conveys the added stress experienced by transgender and gender-nonconforming people when they are diagnosed with gender-associated cancer (e.g., ovarian or prostate cancer) that does not match their gender identity. (posted 9/13/21)
Este artículo está disponible en español.
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Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Study : Cancer risks of people with inherited PALB2 mutations
Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: people with inherited PALB2 mutations
In the largest study of people with inherited PALB2 mutations to date, the gene was linked to increased lifetime risk of breast cancer in women and men, ovarian and pancreatic cancer but not prostate or colorectal cancer. (posted 7/1/21)
Este artículo está disponible en español.
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Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Study : Birth control pills may offer long-term protection against endometrial and ovarian cancer
Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: People concerned about endometrial, ovarian or breast cancer risk
A large study showed that birth control pills may protect against endometrial and ovarian cancers, even years after use was discontinued. (posted 6/1/21)
Este artículo está disponible en español.
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Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Study : Daily high-dose aspirin taken for at least 2 years reduces the risk of colorectal cancer but not other cancers in people with Lynch syndrome
Relevance: High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: People with Lynch syndrome
Research has shown that daily aspirin use can reduce the risk of colon and other cancers. The Cancer Prevention Program 2 (CaPP2) study looked at the effect of daily aspirin in patients with Lynch syndrome. After 10 years of follow-up, the results showed that taking daily aspirin for two years reduced the frequency of colon cancer in patients with Lynch syndrome, and importantly, did not result in an increase in side-effects or complications. No benefit was seen for other Lynch syndrome-related cancers, including endometrial cancer. (5/17/21)
Este artículo está disponible en español.
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