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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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71 through 80 of 325

Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Post Approval

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Study : More is not better: PARP dose can be safely reduced for people with ovarian cancer

Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Post Approval

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Most relevant for: People taking a PARP inhibitor for ovarian cancer maintenance therapy

Maintenance therapy with a PARP inhibitor is now the standard of care for many people with advanced or recurrent ovarian cancer. However, PARP inhibitors may have significant side effects. This study shows that reducing the dose of a PARP inhibitor does not affect survival. (Posted 11/8/22)

Este artículo está disponible en español.

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Relevance: High

Research Timeline: Post Approval

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Update : Strategies for managing pancreatic cancer pain

Relevance: High

Research Timeline: Post Approval

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Most relevant for: People with pancreatic cancer who are dealing with related pain.

Abdominal pain is often a severe, ongoing symptom of pancreatic cancer, yet little research has been done on how to best reduce this pain. The authors of this review discuss current strategies for managing cancer-related pain and their effectiveness. (Posted 10/31/22)

Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

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Study : Resistant starch may help prevent some cancers in people with Lynch syndrome

Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: People with Lynch syndrome and people with a personal and/or family history that suggests Lynch syndrome

This study looked at whether a type of nutrient known as resistant starch could lower the risk of cancers in people with Lynch Syndrome. Researchers found that resistant starch can reduce the risk of non-colorectal cancers but not colorectal cancer. (Posted 10/17/22)

Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: Medium-High

Study : Teens and young adults respond well to learning about familial cancer risk

Relevance: Medium-High

Strength of Science: Medium-High

Most relevant for: Mothers who have had genetic testing for BRCA1 or BRCA2 whether or not they have been diagnosed with breast or ovarian cancer

Little is known about how awareness of hereditary cancer in a high-risk family affects the quality of life of teens and young adults. This study looked at the lifestyle choices, cancer awareness and quality of life of adolescents and young adults whose mothers had undergone testing for a BRCA mutation. (Posted 10/11/2022) Este artículo está disponible en español.

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Relevance: High

Research Timeline: Post Approval

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Update : PARP inhibitors withdrawn as third-line or later treatment for recurrent ovarian cancer

Relevance: High

Research Timeline: Post Approval

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Most relevant for: people with recurrent ovarian cancer who have received 3 or more prior lines of treatment and who have an inherited or tumor mutation in BRCA1 or BRCA2 or whose tumor is HRD positive

Survival data from a clinical trial signaled that PARP inhibitors may not work as well as chemotherapy for patients with recurrent ovarian cancer who have received three or more lines of treatment. As a result, FDA approvals have been withdrawn for PARP inhibitors in this setting.  This does not affect PARP inhibitor approvals for use as maintenance therapy for ovarian cancer. (Posted 10/4/22)

Este artículo está disponible en español.

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Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

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Study : Acupuncture may ease breast cancer treatment side effects

Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

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Most relevant for: People considering acupuncture for managing breast cancer treatment symptoms.

Acupuncture can ease some symptoms of breast cancer treatment. Multiple studies found that acupuncture is a safe and effective strategy to manage certain symptoms but also called for more rigorous research on the topic. (Posted 9/28/22) Este artículo está disponible en español.

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Relevance: Medium

Research Timeline: Post Approval

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Update : FDA reports on new cancers linked to breast implants

Relevance: Medium

Research Timeline: Post Approval

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Most relevant for: People with breast implants

New cancers have been found in women with both textured and smooth implants that are filled with either saline or silicone. These cancers are extremely rare. The FDA has reported cases of a type of skin cancer and blood cancers in the scar tissue that forms around breast implants. The newly reported lymphomas are different from the previously reported breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). (Posted 9/27/22). Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: Medium-High

Study : Expanding Medicaid reduced racial disparities among people with metastatic breast cancer

Relevance: Medium-High

Strength of Science: Medium-High

Most relevant for: People diagnosed with de novo stage 4 breast cancer and people who live in states that have not expanded Medicaid.

The Affordable Care Act allowed more people to access insurance through Medicaid. This study found the expansion of care improved survival and decreased mortality among people of color with de novo stage 4 (stage 4 at the time of initial diagnosis) breast cancer.  (Posted 9/13/2022). Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Study : PARP inhibitor treatment for metastatic prostate cancer shows most benefit in men with inherited BRCA mutations

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: People with metastatic castration resistant prostate cancer who have an inherited or tumor mutation in BRCA2.

This study looked at the benefit of using the PARP inhibitor niraparib to treat metastatic castration-resistant prostate cancer (mCRPC). Participants included those with an inherited or tumor mutation in BRCA1 or BRCA2 or an inherited or tumor mutation in another gene that affects DNA repair. Participants with an inherited or tumor mutation in BRCA1 or BRCA2 had better survival compared to those without a BRCA mutation. Side effects from niraparib were common, and consistent with previous reports for PARP inhibitors.  (posted 9/6/2022)

Este artículo está disponible en español.

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Study : Screening for pancreatic cancer detects early-stage disease and improves survival

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: People at increased risk for pancreatic cancer because of family history or an inherited mutation.

A research study has shown that screening for pancreatic cancer in people with an inherited mutation or family history was able to detect early-stage pancreatic cancers and improve survival. These results will likely change pancreatic cancer screening guidelines for high-risk individuals (Posted 8/30/22)

Este artículo está disponible en español.

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