HOXB13 Gene Mutations
Information about Inherited Mutations
What is ?
is a gene that helps control cell growth. People who are born with changes—called mutations—in their gene have an increased risk for certain types of cancer.
What are the cancer risks associated with ?
Mutations in the have been linked with an increased risk for cancer. There is not enough research to conclude that a mutation increases the risk of other cancers.
What can people with a mutation do?
There are guidelines for cancer screening for people with mutations.
People with an inherited mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
If you test positive for a mutation, you should inform your close blood relatives about your test results and encourage them to speak with a genetics expert.
More detailed information for people with inherited mutations is highlighted below.
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Information for People with Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited HOXB13 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a HOXB13 mutation.
Cancer Treatment Options
People who test positive for a HOXB13 mutation may have additional treatment or clinical trial options available to them.
Participate in Research
The cancer screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier: NCT03805919
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier: NCT05129605
Screening in Men at High Risk of Developing Prostate Cancer
Clinicaltrials.gov identifier: NCT05608694