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TP53 Gene Mutations (Li-Fraumeni Syndrome)

Learn about the cancer risks, screening, prevention and treatment options for people with inherited TP53 mutations. Stay up to date by signing up for our community newsletter.
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Information for People with Inherited Mutations ()

What is a mutation?

Inherited mutations cause a condition known as .

What are the cancer risks for people with a mutation?

People with an in have a very high lifetime risk for different types of cancers, including:

  • brain cancer
  • breast cancer
  • colorectal cancer
  • pancreatic cancer
  • sarcomas
  • other cancers

The risks for cancer begin at a very young age.

What can people with a mutation do?

There are expert guidelines with recommendations for screening and prevention of these cancers. 

There may be family planning considerations and options for people with an inherited mutation. 

Each of these topics is outlined in more detail in the sections highlighted below. 

In the News

Living a full life with Li-Fraumeni syndrome

Personal Story : Living a full life with Li-Fraumeni syndrome

This XRAY review is about a five-time cancer survivor who has an inherited mutation in the TP53 gene. People with...

More Information on Mutations

Cancer Risks

Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations. 

More info

Risk Management Options

Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.   

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Cancer Treatment Options

People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. 

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Other Considerations

People with mutations can develop cancer beginning at an early age. Learn about other important considerations for people with inherited mutations. 

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Participate in Research

The studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool

Last updated September 06, 2024