TP53 Gene Mutations (Li-Fraumeni Syndrome)
Information for People with Inherited Mutations
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What is a mutation?
Inherited mutations cause a condition known as .
What are the cancer risks for people with a mutation?
People with an in have a very high lifetime risk for different types of cancers, including:
- brain cancer
- breast cancer
- colorectal cancer
- pancreatic cancer
- sarcomas
- other cancers
The risks for cancer begin at a very young age.
What can people with a mutation do?
There are expert guidelines with recommendations for screening and prevention of these cancers.
There may be family planning considerations and options for people with an inherited mutation.
Each of these topics is outlined in more detail in the highlighted sections.
In the News
Personal Story : Living a full life with Li-Fraumeni syndrome
This XRAY review is about a five-time cancer survivor who has an inherited mutation in the TP53 gene. People with...
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited TP53 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a TP53 mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with a TP53 mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
People with TP53 mutations can develop cancer beginning at an early age. Learn about other important considerations for people with inherited TP53 mutations.
More Resources
Participate in Research
The studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier: NCT03805919
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier: NCT05129605
Observing People and Families Affected by Li-Fraumeni Syndrome (TP53 Mutation )
Clinicaltrials.gov identifier: NCT01443468