Endometrial Cancer Risk Management
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Every woman is at risk for endometrial cancer; the risk increases with age. The average lifetime risk for endometrial cancer is about 3 percent. This means that 1 in every 33 women will develop endometrial cancer in her lifetime. Note that when we use "women" we are referring to people assigned female at birth.
An inherited mutation in one of the genes listed below increases the risk for endometrial cancer, often at a younger age.
Genes with Endometrial Cancer Risk-Management Guidelines |
*Uterine serous carcinoma is a rare type of endometrial cancer that has been linked to BRCA1 and and BRCA2 mutations. Because this cancer type is rare even in mutation carriers, the overall risk for endometrial cancer with BRCA1 and BRCA2 is not considered high. Researchers continue to study the link between inherited mutations and endometrial cancer. |
Genetic counseling and testing can help you learn if you have an inherited mutation in one of these genes. There are different expert guidelines for endometrial cancer risk management, depending on your level of risk. Speak with your healthcare provider to decide on a risk-management plan and schedule that is right for you.
See below for more information about different risk-management options.
In the News
Study : Hair straightening products linked to small increased risk of endometrial cancer
Many people use products to straighten their hair. Use of these products, especially frequent use, is linked to a small increase in endometrial cancer. (Posted 4/18/23) Este artículo está disponible en español.
Risk-Management Options
Screening
Screening for endometrial cancer uses tests to try to catch cancer in its early stages. In high-risk people, regular screening for endometrial cancer may not improve cancer outcomes. High-risk people should discuss the benefits and limitations of endometrial screening with their doctor.
Medications to Reduce Risk
Medications may lower the risk of endometrial cancer in people with inherited mutations. More research is needed to help experts understand how well these medications work, and which patients will benefit most from their use.
Surgery to Reduce Risk
A hysterectomy is surgery to remove the uterus. People with a very high risk for endometrial cancer, may choose to have a hysterectomy to lower their risk. Read more about the guidelines and surgical options.