Genes with inherited mutations linked to breast cancer

Multi-gene panel tests look for inherited mutations in many genes at the same time. These tests may include new or less common genes. Some panels may include additional genes other than those listed below. A genetics expert can make sure that the most appropriate test is ordered based on your personal situation and family medical history. They will also make sure that your test results are interpreted correctly.

Genes linked to breast cancer in women

Mutations in the following  have been linked to increased risk for breast cancer in women.

ATM	PALB2
BARD1 (especially triple-negative breast cancer)	PTEN
BRCA1 (especially triple-negative breast cancer)	RAD51C (especially triple-negative breast cancer)
BRCA2	RAD51D (especially triple-negative breast cancer)
CDH1	STK11
CHEK2	TP53
NF1 (only in people with neurofibromatosis)

Mutations in the following genes may also be linked to increased breast cancer risk. More research is needed to confirm a link to breast cancer and develop risk-management guidelines. 

• BRIP1 (especially triple-negative breast cancer)
• NBN (only in people with a 657del5 mutation)

Genes linked to breast cancer in men

Mutations in the following genes have been linked to breast cancer risk in men.

• BRCA1 
• BRCA2
• CHEK2 
• PALB2