Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients, CORAL Study
Prevention
People with Lynch Syndrome at risk for colon cancer
Clinicaltrials.gov identifier:NCT05410977
Study Contact Information:
For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email mayocliniccancerstudies@mayo.edu
About the Study
This study will determine the effectiveness of a screening technique, multitarget stool testing, for the detection of colorectal cancer in individuals with . Multitarget stool testing uses stool samples to look for signs of colon cancer. This study will also create a collection of blood and stool samples from individuals with and early onset colorectal cancer (diagnosed younger than 50 years old).
This Study is Open To:
Patients 18 years or older who have:
- A diagnosis of (mutation in , , , , or ) OR who have suspected OR who have been diagnosed with early onset colorectal cancer (diagnosed younger than 50 years old)
- A colonoscopy OR flexible sigmoidoscopy scheduled 90 days before or after sample collection
This Study is NOT Open To:
People who do not meet the inclusion criteria defined above and those who:
- Have had cancer in the 5 years before sample collection (not including some skin cancers)
- Have had chemotherapy for cancer treatment in the 5 years before sample collection
- Have had abdominal radiation before sample collection
- Have had therapy to remove or shrink a colorectal lesion before sample collection
- Have a diagnosis of non-Lynch hereditary colon cancer syndrome such as familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), (PJS), juvenile polyposis syndrome (JPS), , or POL
What the Study Involves
Patients will give blood and stool samples no more than 90 days before or between 7-90 days after their routine colonoscopy or flexible sigmoidoscopy (using a flexible tube with a video camera to examine the colon and rectum.). Patients will also give the researchers permission to look at their medical records.
Study Contact Information:
For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email mayocliniccancerstudies@mayo.edu
Locations:
Arizona
City: Scottsdale RECRUITING
Facility: Mayo Clinic in Arizona
Contact Info:
mayocliniccancerstudies@mayo.edu
855-776-0015
Niloy J. Samadder, M.D.
Florida
City: Jacksonville RECRUITING
Facility: Mayo Clinic in Florida
Contact Info:
mayocliniccancerstudies@mayo.edu
855-776-0015
Douglas L. Riegert-Johnson, MD
Minnesota
City: Rochester RECRUITING
Facility: Mayo Clinic
Contact Info:
mayocliniccancerstudies@mayo.edu
855-776-0015
John Kisiel, M.D.
Prevention
People with Lynch Syndrome at risk for colon cancer
Clinicaltrials.gov identifier:NCT05410977
Study Contact Information:
For additional information, please contact: the Clinical Trials Referral Office by phone 855-776-0015 or by email mayocliniccancerstudies@mayo.edu