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Hereditary Breast Cancer Treatment Study (Treatment Study)

Surveys, Registries, Interviews
The Treatment Study is an international research study to better understand breast cancer treatment among individuals with ATM, CHEK2 and PALB2 gene mutations

Study Contact Information:

You can reach the study team by emailing TreatmentStudy@wchospital.ca or calling 416-323-6400 ext.2749 or ext.5125


Hereditary Breast Cancer Treatment Study (Treatment Study)

About the Study

The Treatment Study is an international research study to better understand breast cancer treatment among individuals with , and gene mutations. Participants are asked to complete online or paper study questionnaires (every two years for 10 years) and share their family history, medical, and genetics records.

Research shows that , and mutations increase the risk of developing breast cancer; however, it is not clear how to best treat or reduce the risk of these hereditary breast cancers. Learning more about breast cancer among those with , and mutations will help to better understand: 

  • If people with -, - and -associated breast cancer have an increased risk of developing a new breast cancer
  • The best treatment for breast cancer patients with an , or mutation and how to improve survival outcomes
  • How healthy family members who carry , and mutations can best manage their cancer risks (through screening, preventive surgery, etc.)

Through a better understanding of these hereditary breast cancers, we can personalize breast cancer treatment to improve survival and determine how to best manage at risk family members to detect cancer early or prevent it.

What the Study Entails

You do not have to travel to participate; all study forms and questionnaires can be completed from home. If you choose to participate, you will be asked to:

  • Complete a consent form indicating your willingness to participate
  • Provide contact information for yourself and an alternate contact
  • Complete a questionnaire about your breast cancer at the beginning of the study and follow-up questionnaires every two years for 10 years to record and changes in your health (total of six questionnaires)
  • Provide your family history
  • Give permission to the study to collect medical records about your genetic test results and your cancer diagnosis and treatment                                                                            

Study Lead Investigator

Kelly Metcalfe, PhD

This Study is Open To:

You are eligible to participate in this study if you meet all of the following criteria:

  • You have an , or mutation and
  • You were diagnosed with breast cancer in the year 2000 or later and
  • Your breast cancer was your first diagnosis of cancer and
  • You were assigned female at birth and
  • You can read and understand English.
This Study is Not Open To:

The study is not open to people who do not meet all of the criteria above.