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Education > XRAY > Metastatic Breast Cancer

FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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Metastatic Breast Cancer

41 through 50 of 113

Relevance: High

Strength of Science: High

Quality of Writing: High

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Study : Among women with breast cancer, who should have genetic testing for an inherited mutation?

Relevance: High

Strength of Science: High

Quality of Writing: High

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Most relevant for: Women diagnosed with breast cancer who do not know if they have an inherited mutation in a gene linked to breast cancer

Which breast cancer patients should consider genetic testing? Knowing whether you have an inherited mutation may inform the decisions you and your healthcare provider make about treatment. But it can also increase stress and anxiety. This XRAY reviews a study of how different guidelines affect genetic testing recommendations for people with breast cancer. (8/27/20)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Study : Promising research using a PARP inhibitor to treat metastatic breast cancer in people with an inherited PALB2 mutation or a tumor mutation in BRCA1 or BRCA2

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: People with metastatic breast cancer with an inherited mutation in PALB2 or tumor with a BRCA mutation

Early results of a small study showed that women with metastatic breast cancer and an inherited  mutation in PALB2 or an acquired tumor mutation in BRCA1 or BRCA2 benefitted from the PARP inhibitor olaparib (Lynparza). (6/18/20)

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Relevance: High

Research Timeline: Post Approval

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Update : FDA approves tucatinib (Tukysa) for metastatic Her2-positive breast cancer

Relevance: High

Research Timeline: Post Approval

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Most relevant for: Patients with Her2-positive metastatic breast cancer

The FDA has approved the use of tucatinib (Tukysa) in combination with chemotherapy as a treatment for people with metastatic Her2-positive breast cancer. This  approval includes treatment of people whose breast cancer has spread to the brain. (4/29/20)

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Relevance: High

Research Timeline: Post Approval

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Update : FDA approves new treatment for metastatic triple-negative breast cancer

Relevance: High

Research Timeline: Post Approval

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Most relevant for: People with metastatic triple-negative breast cancer who have received at least two prior lines of treatment

The FDA approved the use of sacituzumab govitecan-hizy (Trodelvy), a treatment drug for people with metastatic triple-negative breast cancer who have received at least two prior therapies for metastatic disease. (4/27/20)

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Relevance: High

Quality of Writing: High

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Personal Story : Improving the quality of life for people with metastatic breast cancer

Relevance: High

Quality of Writing: High

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Most relevant for: People diagnosed with metastatic breast cancer

Washington Post article described the cancer experience of a young woman living with metastatic breast cancer. It also highlights how integrative medicine and palliative care, including acupuncture, massage, yoga, pain management, mental health therapy and nutrition can improve quality of life for people with metastatic cancer. (3/10/20)

Este artículo está disponible en español.

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Human Research

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Study : A new breast cancer drug improves overall survival among people with brain and other metastases

Relevance: Medium-High

Strength of Science: High

Research Timeline: Human Research

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Most relevant for: People with metastatic breast cancer

A promising new drug called tucatinib combined with standard therapy shows benefit for women with HER2-positive metastatic breast cancer. Women who took tucatinib experienced longer progression-free survival (time before their cancer worsened), longer overall survival time and response of cancer (shrinking or disappearing). Strikingly, better outcomes were also seen for women with brain metastases, which is often difficult to treat. (12/20/19) 

THIS INFORMATION HAS BEEN UPDATED on 04/17/20:  The U.S. Food and Drug Administration has approved Tukysa (tucatinib) for use in combination with trastuzumab (Herceptin) and capecitabine for patients with advanced or metastatic HER2-positive breast cancer, including patients with brain metastases (disease that has spread to the brain). Patients who have received one or more treatments targeting Her2 in the metastic setting are eligible to receive Tukysa. Tukysa  is an oral (tablet) tyrosine kinase inhibitor which is taken twice daily. 

 

 

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Relevance: High

Quality of Writing: High

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Personal Story : Running marathons with metastatic breast cancer? Yes!

Relevance: High

Quality of Writing: High

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Most relevant for: Women with metastatic breast cancer

Runner’s World Magazine featured Sarah Smith, a metastatic breast cancer patient who runs marathons and ultra-marathons. By telling her story, Sarah wants to encourage people to stay active, despite the challenges that life may bring. (10/13/19)

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Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Post Approval

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Study : Inherited mutations in metastatic breast cancer patients

Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Post Approval

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Most relevant for: People with metastatic breast cancer

Recent research shows that a significant portion of patients with metastatic breast cancer have harmful mutations in a gene associated with hereditary breast cancer and increased breast cancer risk. (9/26/19)

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Relevance: Medium-High

Research Timeline: Post Approval

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Guideline : FDA issues warning on CDK inhibitors

Relevance: Medium-High

Research Timeline: Post Approval

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Most relevant for: People currently taking a CDK inhibitor

The U.S. Food and Drug Administration issued a safety alert for CDK inhibitors, including Ibrance (palbociclib), Kisqali (ribociclib), and Verzenio (abemaciclib). (9/24/19)

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Relevance: High

Strength of Science: Medium

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Study : Supportive care can improve quality of life for people with metastatic breast cancer

Relevance: High

Strength of Science: Medium

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Most relevant for: People diagnosed with metastatic breast cancer

Metastatic breast cancer patients have unique needs for treatment and care. Connecting patients to appropriate support services and palliative care is an area of need in health care. A recent study reported improvement in metastatic breast cancer patient quality of life and wellness with an intervention program called the Supportive, Education and Advocacy (MBC-SEA) program. (8/21/19)

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