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STK11 (Peutz–Jeghers Syndrome): Cancer Risks

People with an inherited mutation in the STK11 gene have an increased risk for certain types of cancer. Learn about these risks. Stay up to date by signing up for our community newsletter.
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Cancer Risk Associated with Inherited Mutations

If you have tested positive for an mutation, we recommend speaking with a genetics expert who can look at your personal and family history of cancer, and can help you decide on a plan for managing your risk. 

Experts at the National Comprehensive Cancer Network (NCCN) created guidelines which estimate the cancer risks for people with mutations. These cancer risk estimates are updated based on the latest research and include the following:

Cancer Type
Lifetime Risk with STK11 Mutation
Lifetime Risk in General Population

Breast cancer in women (people assigned female at birth)

32 - 54%
12.5%
Colorectal
39%
4.1%
Gastric
29%
0.8%
Ovarian sex cord tumors (may be cancer or benign)
20% or higher

1.1%

Pancreatic
11 - 36%
1.5%
Gastric
5 - 7%
0.8%
Small bowel
13%
0.3%
Lung
7 - 17%
6%
Cervical cancer
10% or higher
No data

Endometrial

9%
3.1%
Testicular (Sertoli cell tumor)
9%
Less than 1%

Source: NCCN: Genetic/Familiar High-Risk Assessment: Colorectal, Endometrial, Gastric; v. 3, 2024.

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:

  • current age
  • gender
  • specific mutation
  • personal and family health history
  • diet, exercise, lifestyle and other factors

Last updated January 02, 2024