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TP53 (Li-Fraumeni Syndrome): Other Considerations

Learn about other health implications for people with Li-Fraumeni syndrome due to a TP53 mutation. Stay up to date by signing up for our community newsletter.
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Other Medical Concerns for People with Inherited Mutations

can have other implications beyond cancer risk. 

What medical conditions besides cancer do people with need to know about?

Research shows that people with  are sensitive to the effects of radiation. Experts recommend that people with avoid radiation exposure as much as possible. 

What can parents do to avoid passing their mutation on to their children?

Because of the high lifetime risk and early onset of medical issues with Li-Fraumeni syndome, people of reproductive age may wish to speak with a fertility expert prior to having children. There are options using assisted reproductive technology and preimplantation genetic diagnosis for parents to select embryos that are free of an inherited mutation. 

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Li-Fraumeni Syndrome Association

LFSA provides information, advocacy and resources for individuals and families with Li-Fraumeni syndrome.
Last updated September 07, 2025