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Cancer Treatment: What Are Biomarker Tests?

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Risk Management & Treatment > Cancer Treatment > Biomarker Testing > Cancer Treatment: What Are Biomarker Tests?

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What are biomarkers?

Cancers are made up of abnormal cells. These cells can produce different types of abnormal substances, including:

  • proteins
  • genetic material (gene mutations, abnormal chromosomes, or RNA, fused genes)
  • cellular material

These abnormal substances are called biomarkers (or tumor markers). Biomarkers may be found within or around tumors, in blood, urine and other body fluids.


Purpose of the test

tests may aid decision-making in different ways:

  • Measuring risk for recurrence: Some tests predict how fast a cancer is growing and the risk for recurrence. Examples include OncotypeDX, Mammaprint and Endopredict for breast cancer and OncotypeDX and Prolaris for cancer. 
  • Monitoring response to treatment, progression or recurrence: These tests often measure changes in biomarkers over time to learn if the cancer is responding to treatment. Examples include CA125 testing to monitor ovarian cancer and testing to monitor cancer.
  • Aiding in treatment selection: Some cancer treatments work best in people with certain biomarkers. In these cases, testing can help identify people who are most likely to respond to a particular treatment. 
  • Detecting cancer:  “Liquid biopsies⁠” look for cancer cells or cancer cell in the blood. These tests are also being studied to see if they can be used for early detection of cancer.  

What type of sample is needed?

  • Some tests may be run on stored tumor tissue that was collected and saved at the time of your diagnosis, even if your biopsy was done a while ago. If you have enough tumor tissue stored, using this "archival tissue" may spare you from a new biopsy. 
  • Some tests require fresh tissue, which means you may need a new biopsy. This is because some tumor biomarkers change over time as cancer cells grow, spread or become resistant to treatments. 
  • Some cancer cells may release biomarkers into the blood, urine or other fluids. This provides a more convenient way to find cancer or to monitor response to treatment without the need for a tissue biopsy. Blood tests that look for abnormal cancer cell are sometimes referred to as circulating tumor tests,  or liquid biopsies. 

Biomarkers for treatment selection

Some targeted therapies and immunotherapies work best in cancers that have specific biomarkers.  tests may be used to select the best to treat a particular cancer. About 100 targeted therapies have approval to treat different types of cancers. You can learn more about testing for treatment selection on our Cancer Treatment by Cancer Type and our Common Biomarkers sections.

Certain genes are important for repairing damage. These are sometimes referred to as " damage repair" (DDR) genes. Some therapies work best in cancers that have faulty DDR genes. You can read more about tests and treatments for these tumors in our Damage Repair section. 


Last updated November 17, 2024