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Prevention

Prevention study for women at high risk for ovarian cancer

Clinicaltrials.gov identifier:
NCT05287451

Study Contact Information:

Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email:  rnitecki@mdanderson.org

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High-Risk Women (TUBA/WISP II)

Prevention

Prevention study for women at high risk for ovarian cancer

Clinicaltrials.gov identifier:
NCT05287451

Study Contact Information:

Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email:  rnitecki@mdanderson.org

PRINTER FRIENDLY PAGE
Glossary on
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About the Study

This study is looking at whether removal of the () followed by removal of the ovaries () at a later date closer to the time of natural menopause may reduce the risk of ovarian cancer nearly as much as removing both the ovaries and at the same time (salpingo-oophorectomy) among women with an inherited , , , or mutation. Removing the only first and the ovaries at a later time closer to natural menopause may lessen menopausal symptoms while still lowering the risk for ovarian cancer.

This Study is Open To:

Women are eligible if they:

Are premenopausal with a documented in one of the genes listed below. Eligible age depends on gene mutation. 

  • BRCA1: 25-40
  • BRCA2: 25-45
  • BRIP1: 30-50
  • RAD51C: 30-50
  • RAD51D: 30-50

Have at least one

Do not wish to be pregnant in the future 

This Study is NOT Open To:

Women cannot participate if they:

  • are post-menopausal (either naturally or due to cancer treatment)
  • wish for second removal of ovaries within 2 years of removing
  • have a personal history of ovarian/fallopian tube or peritoneal cancer 
  • have had prior removal of the (

What the Study Involves

Participants in this study will enroll in one of two groups. Participants will choose which group they enroll in based on their surgical preference. 

  • Group 1 will include women who choose risk-reducing removal of () with delayed
  • Group 2 will include women who choose removal of both and ovaries at the same time, (salpingo-oophorectomy) which is considered standard-of-care.

Study Contact Information:

Contact: Roni Wilke, MD
by phone: (713) 822-4502
or by email:  rnitecki@mdanderson.org

Locations:

Massachusetts

City: Boston RECRUITING
Facility: Harvard Cancer Center
Contact Info:
cfeltmate@bwh.harvard.edu 617-732-8843
Colleen Feltmate, MD

Missouri

City: Saint Louis RECRUITING
Facility: Washington University School of Medicine
Contact Info:
hagemanna@wustl.edu 314-362-3181
Andrea Hagemann, MD

Texas

City: Houston RECRUITING
Facility: M D Anderson Cancer Center
Contact Info:
rnitecki@mdanderson.org 713-822-4502

Washington

City: Seattle RECRUITING
Facility: Fred Hutch/University of Washington/Seattle Children's Cancer Consortium
Contact Info:
bnorquis@uw.edu 206-598-8300
Barbara Norquist, MD