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BRIP1 Gene Mutations

Learn about the cancer risks, screening, prevention and treatment options for people with inherited BRIP1 mutations. Stay up to date by signing up for our community newsletter.
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Information for People with an Inherited Mutation

What are the cancer risks for people with a mutation?

Mutations in the  gene have been linked to increased risk for and ovarian cancer. Researchers are studying whether these mutations increase the risk for other cancers.

What can people with a mutation do?

Expert guidelines include recommendations for people with mutations on managing their cancer risk. 

People with a  mutation who have been diagnosed with some types of cancer may qualify for specific treatments or clinical trials using targeted therapies. 

There may be other medical concerns, including a rare childhood disease known as Fanconi anemia which can happen in people who inherit a mutation in both copies of their gene. 

Each of these topics is outlined in more detail in the sections highlighted below.


More Information on Mutations

Cancer Risks

Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited mutations. 

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Risk Management Options

Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.  

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Cancer Treatment Options

Tumor  testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a mutation may have additional treatment or clinical trial options available to them. 

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Other Considerations

People who inherit a mutation in both copies of their gene—one from each parent—have a rare disease known as Fanconi anemia. Learn additional information about inherited mutations. 

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More Resources


Participate in Prevention Research

The screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool

Participate in Treatment Research

The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool

Last updated February 25, 2024