BRIP1 Gene Mutations
Information for People with an Inherited Mutation
What are the cancer risks for people with a mutation?
Mutations in the gene have been linked to increased risk for and ovarian cancer. Researchers are studying whether these mutations increase the risk for other cancers.
What can people with a mutation do?
Expert guidelines include recommendations for people with mutations on managing their cancer risk.
People with a mutation who have been diagnosed with some types of cancer may qualify for specific treatments or clinical trials using targeted therapies.
There may be other medical concerns, including a rare childhood disease known as Fanconi anemia which can happen in people who inherit a mutation in both copies of their gene.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited BRIP1 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a BRIP1 mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor biomarker testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a BRIP1 mutation may have additional treatment or clinical trial options available to them.
Other Considerations
People who inherit a mutation in both copies of their BRIP1 gene—one from each parent—have a rare disease known as Fanconi anemia. Learn additional information about inherited BRIP1 mutations.
More Resources
Participate in Prevention Research
The screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier: NCT03805919
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier: NCT05129605
Clinicaltrials.gov identifier: NCT05287451
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
