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BRIP1 Gene Mutations: Cancer Risk

Learn about the cancer risks associated with mutations in the BRIP1 gene. Stay up to date by signing up for our community newsletter.
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Cancer Risk Associated with Inherited Mutations

If you have tested positive for a mutation, we recommend you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your cancer risk. 

, ovarian and primary peritoneal cancer risks

People with a mutation have a 5-15% lifetime risk of , ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer.

Other cancer risks for people with a mutation

There is not yet enough research to conclude that a mutation is associated with an increased risk of other adult-onset cancers. Research on the risk for cancer in people with mutations is ongoing. 

It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:

  • current age
  • sex assigned at birth
  • specific mutation
  • personal and family health history
  • diet, exercise, lifestyle and other factors

Participate in Research

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy

Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy

Clinicaltrials.gov identifier:
NCT05287451

Prevention
Prevention study for women at high risk for ovarian cancer

This study is looking at whether removal of the fallopian tubes (salpingectomy) followed by removal of the ovaries (oophorectomy) at a later date closer to the time of natural menopause may reduce the risk of...

Last updated June 21, 2024