BRIP1 Gene Mutations: Cancer Risk
Cancer Risk Associated with Inherited Mutations
If you have tested positive for a mutation, we recommend you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your cancer risk.
, ovarian and primary peritoneal cancer risks
People with a mutation have a 5-15% lifetime risk of , ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer.
Other cancer risks for people with a mutation
There is not yet enough research to conclude that a mutation is associated with an increased risk of other adult-onset cancers. Research on the risk for cancer in people with mutations is ongoing.
It is important to note that cancer risks are estimates over the course of a person's lifetime. Your lifetime risk and risk over the next five years will vary depending on:
- current age
- sex assigned at birth
- specific mutation
- personal and family health history
- diet, exercise, lifestyle and other factors
Participate in Research
Clinicaltrials.gov identifier:
NCT05287451
Prevention
Prevention study for women at high risk for ovarian cancer
This study is looking at whether removal of the fallopian tubes (salpingectomy) followed by removal of the ovaries (oophorectomy) at a later date closer to the time of natural menopause may reduce the risk of...