RAD51D: Options for Cancer Treatment
Cancer Treatment for People with Inherited Mutations
Testing positive for an inherited mutation may affect your treatment options or eligibility for clinical trials studying which treatments work best. The following are examples of situations where an mutation may play a part in treatment decision-making. Note that when we use "women" we are referring to people assigned female at birth.
Targeted therapies for advanced cancers
PARP inhibitors are a type of that work by blocking a protein used to repair damaged . People with an mutation who have been diagnosed with cancer may want to ask their doctor about whether they might benefit from therapy or a research study.
PARP inhibitors for advanced ovarian, or primary peritoneal cancer
Several PARP inhibitors have been approved to treat ovarian cancers at different stages of the disease. In some situations, a tumor known as an test ("hemologous recombination deficiency") can help identify which ovarian cancers may respond to treatment with a .
after treatment
- testing can help people with advanced ovarian cancer learn if they may benefit from the , Lynparza () in combination with Avastin (bevacizumab) as after platinum chemotherapy.
- () is approved for in people with advanced ovarian, , or primary peritoneal cancer who had a complete or partial response to platinum-based chemotherapy. for does not require an test.
after treatment of recurrent cancer
- , () and Lynparza are all approved for maintenance therapy in people with recurrent epithelial ovarian, , or primary peritoneal cancer who are in a complete or partial response to platinum based chemotherapy. In this setting, none of these drugs requires an test.
To learn more about treatment options for specific types of cancer, visit our section on Cancer Treatment by Cancer Type.
PARP inhibitors for prostate cancer
The PARP inhibitors, Lynparza () and () have received FDA-approval to treat , (mCRPC), with a mutation in certain genes linked to a certain type of damage repair.
PARP inhibitors or other targeted therapies for advanced cancers with no other treatment options
If you have a mutation and another type of advanced cancer that no longer responds to standard therapy, you may want to talk with your doctor about whether you might benefit from treatment with a or participation in a clinical trial.
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Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
