PTEN: Options for Cancer Treatment
Cancer Treatment for People with Mutations
People with an inherited mutation who have been diagnosed with cancer may have different treatment options than people without a mutation. To learn more about standard of care treatment options for specific types of cancer, visit our section on Cancer Treatment by Cancer Type.
If you have an inherited mutation, have been diagnosed with cancer and the situations below apply to you, you may wish to speak to your doctor about your medical options.
- You are making breast cancer surgical decisions
- You have , breast cancer
- You have another type of advanced cancer
Regardless of cancer type, people with a mutation may benefit from testing and may qualify for clinical trials looking for more effective treatments for cancer.
Note that when we use the term "women" we are referring to people assigned female at birth.
Surgical decisions for a breast cancer diagnosis
Because of the increased risk for a second breast cancer diagnosis, women who are diagnosed with breast cancer who test positive for an in may choose mastectomy rather than and radiation. Mutation carriers who undergo mastectomy are less likely to develop a second breast cancer.
The Truqap (capivasertib) is a type of drug known as an AKT inhibitor. AKT inhibitors may be effective for treating cancer in people with mutations.
or advanced breast cancer
Truqap combined with fulvestrant is approved to treat , advanced or breast cancer with a mutation in , PIK3 or AKT1 genes which recurred or got worse after standard hormone therapy.
Other types of advanced or cancers
Although not approved for other types of cancer, AKT inhibitors are being studied in other types of cancer, including advanced endometrial cancer. If you have advanced cancer for which there is no approved treatment yet, you may want to speak with their doctor about using Truqap "off-label" or look for a clinical trial using an AKT inhibitor.
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