Get notified of page updates

HOXB13 Gene Mutations: Cancer Risk

Learn about the cancer risks associated with mutations in the HOXB13 gene. Stay up to date by signing up for our community newsletter.
Glossary on
off

Cancer Risk Associated with Inherited Mutations

If you have tested positive for an inherited mutation, we recommend consulting with a genetics expert who can look at your personal and family history of cancer and can help you decide on a risk-management plan. 

Note that when we use the term "men" we are referring to the sex you were assigned at birth.

cancer risks

mutations increase the risk for  cancer. This risk may be associated with a younger age of diagnosis. More research is needed to better measure the lifetime cancer risk associated with a mutation in this gene. 

Other cancer risks for people with a mutation

There is not yet enough research to conclude that a mutation increases the risk of other cancers. Research on the risk for cancer in people with mutations is ongoing. 

Participate in Research

The cancer screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

Clinicaltrials.gov identifier:
NCT04472338

Prevention
Screening study for people with a mutation linked to prostate cancer risk

The PATROL (Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease) study is for people at risk for prostate cancer because they carry one or more genes that are known or suspected to...

Screening Study for Men at High Genetic Risk for Prostate Cancer

Screening Study for Men at High Genetic Risk for Prostate Cancer

Clinicaltrials.gov identifier:
NCT03805919

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation

The National Institutes of Health has a clinical trial for men at high genetic risk for prostate cancer. This is trial is for men without prostate cancer, ages 30 to 75, who have tested positive...

Screening in Men at High Risk of Developing Prostate Cancer

Screening in Men at High Risk of Developing Prostate Cancer

Clinicaltrials.gov identifier:
NCT05608694

Prevention
Screening using MRI for men at risk of developing prostate cancer

This study will determine if prostate magnetic resonance imaging (MRI) will find prostate cancer in men at high risk of developing prostate cancer.

Upright MRI for Prostate Cancer Screening

Upright MRI for Prostate Cancer Screening

Clinicaltrials.gov identifier:
NCT03474913

Prevention
Screening for prostate cancer using upright MRI

This study will compare the effectiveness of an upright magnetic resonance imaging (MRI) compared to prostate specific antigen (PSA) and current MRI imaging for prostate cancer screening.


More Resources

Last updated December 31, 2023