MSH2 (Lynch Syndrome): Risk Management
Risk Management for People with an Inherited Mutation
People with mutations have options for managing their increased cancer risk. Experts at the National Comprehensive Cancer Network (NCCN) created guidelines for people with an mutation to manage their cancer risk.
We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your risk.
Risk management guidelines
NCCN recommends that all people with an inherited mutation receive education on the signs and symptoms of Lynch syndrome-related cancers. NCCN guidelines for specific cancers are listed below. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type.
NCCN risk management guidelines for people with mutations include information on the following cancers:
People with an mutation may also qualify for clinical trials looking for more effective screening or prevention for cancer.
Participate in Research
In the News
Beginning Age |
Recommendation |
20-25 (or 2-5 years before the earliest age of colon cancer in the family, if diagnosed before age 25) |
High quality colonoscopy every 1-2 years. Speak with your doctor about whether your screenings should be yearly or every two years. Men, people over age 40, and people with a personal history of colon cancer or colon polyps may benefit most from yearly screenings. |
No set age |
Daily aspirin can decrease the risk for colorectal cancer. The best dose and timing for aspirin is not known. Speak with your doctor about the benefits and risks, best timing and dose. |
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric; v1. 2 2024 |
Beginning Age |
Recommendation |
Additional Information |
No set age |
Endometrial cancer can often be caught early based on symptom awareness followed by a biopsy. Learn to be aware of the symptoms of endometrial cancer and immediately report any symptoms to your doctor. Keep a diary of menstrual cycles in order to detect any changes in bleeding. |
Symptoms of endometrial cancer include:
|
30-35 |
Discuss the benefits, risks and costs of an endometrial biospsy every 1-2 years with your doctor. |
Endometrial cancer screening does not have proven benefit in individuals with Lynch syndrome. However, endometrial biopsy is an accurate test for finding cancer. |
After menopause |
Discuss the benefits, risks and costs of regular endometrial cancer screening through transvaginal ultrasound. |
Endometrial cancer screening does not have proven benefit in individuals with Lynch syndrome. Despite this, some people prefer to undergo regular screening through transvaginal ultrasound. |
After age 40 (or personalized based on childbearing plans) |
Discuss the benefits, risks and costs of a risk-reducing hysterectomy (surgical removal of the uterus) and salpingectomy (surgical removal of the fallopian tubes). |
|
No specified age |
Speak with your doctor about the benefits, risks and timing of oral contraceptives or progestin intrauterine devices (IUD). |
Oral contraceptive pills (birth control) and progestin intrauterine devices (IUD) may lower the risk for endometrial cancer associated with Lynch syndrome. |
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric; v1. 2 2024 |
Beginning Age |
Recommendation |
Additional Information |
No set age |
Be aware of ovarian cancer symptoms. Report any of the following symptoms that persist for several weeks and are a change from normal to your doctor. Routine ovarian cancer screening using transvaginal ultrasound and a CA-125 blood test has not shown benefit and is not recommended. |
Symptoms of ovarian cancer include:
|
After completion of child-bearing |
Speak with your doctor about the benefits, risks and timing of risk-reducing removal of ovaries and fallopian tubes (RRSO). |
|
No set age |
Speak with your doctor about the benefits, risks and timing of oral contraceptives or progestin intrauterine devices (IUD). |
Oral contraceptive pills (birth control) and progestin intrauterine devices (IUD) may lower the risk for ovarian cancer associated with Lynch syndrome. |
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric; v1. 2 2024 |
Pancreatic cancer
There are two tests that are used to look for pancreatic cancer in high-risk people.
- MRCP (Contrast-enhanced magnetic resonance cholangiopancreatography) is a special type of imaging that looks closely at the pancreas, liver, gallbladder, bile duct and pancreatic duct to find abnormalities such as cancer.
- EUS (Endoscopic ) involves passing a tiny scope with an attached probe down the esophagus to the stomach. This allows doctors to look closely at the pancreas.
Beginning Age |
Recommendation |
|
50 (or younger based on family history) |
For MSH2 mutation carriers with a first- or second- degree relative with pancreatic cancer
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Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic vs. 3 2024. |
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Beginning Age |
Recommendation |
|
30-35 |
For MSH2 mutation carriers with a relative with bladder, kidney or ureteral cancer
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|
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Gastric vs. 1 2024 |
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Beginning Age |
Recommendation |
|
40 |
Have a conversation with your doctor about the potential benefits, risks, costs and limitations of screening for prostate cancer.
|
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Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Gastric vs. 1 2024 |
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Beginning Age |
Recommendation |
|
30-40 (or younger based on family history) |
Begin stomach cancer screening using a procedure known as EGD (esophagogastroduodenocopy) and repeat every 2-4 years.
|
|
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Gastric vs. 1 2024 |
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Beginning Age |
Recommendation |
|
No set age |
Learn the signs of brain cancer and report any symptoms to your doctor. |
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Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Gastric vs. 1 2024 |
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Beginning Age |
Recommendation |
|
No set age |
Talk with your doctor about the benefits of having a skin exam every 1-2 years with an expert trained in finding skin changes related to Lynch syndrome |
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Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Gastric vs. 1 2024 |
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Other cancers
The guidelines do not address screening or prevention of other cancers for people with mutations. However, clinical trials may be available.
More Resources
Participate in Prevention Research
Below are some of our featured research studies looking at new ways to screen for, prevent or intercept cancer in people with mutations. To search for additional studies, visit our Search and Enroll Tool.
Pancreatic Cancer Screening Study (CAPS5)
Clinicaltrials.gov identifier:
NCT02000089
The DETECT Study: Detecting Endometrial Cancer in Tampons
Clinicaltrials.gov identifier:
NCT03538665
Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05419011
Early Detection of Colorectal Cancer for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05410977
Clinicaltrials.gov identifier:
NCT05396846
Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05411718
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December 28, 2020