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PMS2: Risk Management

People with a PMS2 mutation have options for managing their cancer risk. Learn about the screening and prevention guidelines. Stay up to date by signing up for our community newsletter.

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Risk Management for People with an Inherited Mutation

People with mutations have options for managing their increased cancer risk. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your risk.

Risk management guidelines

NCCN provides risk management guidelines for people with mutations. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type.

NCCN risk management guidelines for people with mutations include information on the following cancers. People with an mutation may also qualify for clinical trials looking for more effective screening or prevention for cancer.

Colorectal

Endometrial

Other cancers

Colorectal cancer

Beginning Age	Recommendation
30-35 (or 2-5 years before the earliest age of colon cancer in the family, if diagnosed before age 30)	High quality colonoscopy every 1-3 years. Speak with your doctor about how often you should have a colonoscopy. Men, people over age 40, and people with a personal history of colon cancer or colon may benefit most from yearly screenings.
No set age	Daily aspirin can decrease the risk for colorectal cancer. The best dose and timing for aspirin is not known. Speak with your doctor about the benefits and risks, best timing and dose.
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric; v. 1, 2025.

Endometrial cancer

Beginning Age	Recommendation	Additional Information
No set age	Endometrial cancer can often be caught early based on symptom awareness followed by a biopsy. Learn to be aware of the symptoms of endometrial cancer and immediately report any symptoms to your doctor. Keep a diary of menstrual cycles in order to detect any changes in bleeding.	Symptoms of endometrial cancer include: unusual vaginal bleeding pelvic or abdominal pain bloating or distended belly difficulty eating increased urination or pressure to urinate
30-35	Discuss the benefits, risks and costs of an endometrial biopsy every 1-2 years with your doctor.	Endometrial cancer screening does not have proven benefit in individuals with . However, endometrial biopsy is an accurate test for finding cancer.
After menopause	Discuss the benefits, risks and costs of regular endometrial cancer screening through transvaginal .	Endometrial cancer screening does not have proven benefit in individuals with . Despite this, some people prefer to undergo regular screening through transvaginal .
After age 50 (or personalized based on childbearing plans)	Discuss the benefits, risks and costs of a risk-reducing hysterectomy (surgical removal of the uterus) and (surgical removal of the ).	For people who need colorectal surgery, consider coordinating hysterectomy at the same time. Total hysterectomy lowers the risk, but it has not been shown to reduce death from endometrial cancer.
No specified age	Speak with your doctor about the benefits, risks and timing of oral contraceptives or intrauterine devices (IUD).	Oral contraceptive pills (birth control) and intrauterine devices (IUD) may lower the risk for endometrial cancer associated with .
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric; v. 1, 2025.

Other cancers

NCCN includes risk-management guidelines for additional cancers in people with other genes. However, they note that there is very little research to prove that people with mutations benefit from risk-management for other cancers unless there is also a family history of these cancers. In their 2025 guidelines, NCCN removed recommendations for risk management for additional cancers from the guidelines.

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Participate in Prevention Research

Below are some of our featured research studies looking at new ways to screen for, prevent or intercept cancer in people with mutations. To search for additional studies, visit our Search and Enroll Tool.